A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant

To be considered for this study, your child must be between 1 and 17 years old and weigh at least 6 kilograms (about 13 pounds). They must have had a kidney transplant more than six months ago, and their kidney function needs to be stable. They also need to be taking medicines to prevent their body from rejecting the new kidney, and have been on these medicines for at least a month.

It's important that your child has either had the chickenpox vaccination, a confirmed case of chickenpox, or a blood test showing they've been exposed to the chickenpox virus before their transplant. Parents or legal guardians must be willing to follow all study rules and give their written permission. Older children might also need to agree to take part themselves.

Some conditions would prevent your child from joining. For example, if their original kidney disease had a high chance of returning in the new kidney, or if there's any sign it has already returned in the transplanted kidney. Also, if they've lost a previous transplanted kidney because that original kidney disease came back.

If your child takes part, they will receive two doses of the new vaccine. This will involve several visits to the study clinic where doctors and nurses will check their health, monitor for any side effects, and take blood samples to see how their immune system is responding to the vaccine. They will be carefully looked after throughout the study. The exact number of visits and the total length of time your child would be involved will be explained in full by the study team, but it will involve follow-up after the vaccinations are given.