RekryteringOBSERVATIONELL

Immune Biomarkers in Prostate Cancer Patients Treated With Brachytherapy

This research study is for men with prostate cancer who are receiving a specific type of radiation treatment called brachytherapy. Brachytherapy involves placing tiny radioactive 'seeds' directly into the prostate gland. The study aims to understand how the body's natural defence system, called the immune system, responds to this treatment. Researchers will be looking at cells from the blood and, in some cases, tissue from the prostate itself, before, during, and after brachytherapy. The goal is to discover how these immune markers change and whether they play a role in how well the treatment works against prostate cancer, including cases where the cancer has come back.

Överblick

Status

Rekrytering

Sponsor

University of Erlangen-Nürnberg Medical School

Inskrivningsmål

200

Starta

01 dec 2025

Beräknad slutförande

31 Jul 2028

Prostate Cancer (Diagnosis)Prostate Cancer Patients Who Have Brachytherapy Seed Implant Prostate Cancer Patients Treated by Radiotherapy Prostate Cancer Recurrent

Vad handlar denna studie om?

This study is focused on men with prostate cancer who are undergoing a special type of radiation treatment called brachytherapy. Think of brachytherapy as a very targeted way to deliver radiation directly to the prostate gland using tiny radioactive 'seeds'. The main idea behind this research is to explore how your body's immune system – which is your natural defence against illnesses – reacts to this treatment. We know that the immune system is crucial for fighting diseases like cancer, and researchers want to see if brachytherapy can also help activate or improve the immune response against prostate cancer.

The researchers will be collecting blood samples at different times: before you start brachytherapy, during the treatment period, and after it's completed. From these blood samples, they will carefully examine the immune cells to see how they change over time. In some cases, if you have a biopsy (a procedure to take a small tissue sample) as part of your brachytherapy, those tissue samples will also be looked at to understand the immune system's activity within the prostate itself.

By doing this, the scientists hope to gain a better understanding of how brachytherapy affects your immune system. This could lead to a future where we can predict who will respond best to treatment, or even find new ways to combine brachytherapy with other treatments to make them even more effective at beating prostate cancer.

Viktiga punkter

Study looks at immune system changes during prostate cancer brachytherapy.
It aims to understand how the body's natural defences react to treatment.
Blood and tissue samples will be collected at different times.
Participation will not change your planned cancer treatment.
The findings could help improve future prostate cancer care.

Vem kan vara berättigad?

This study is looking for men aged 18 and over who have prostate cancer.

There are two main groups for this study. The first group is for men who are having brachytherapy for the first time as their main treatment for prostate cancer. This means they haven't had any other treatments for their prostate cancer before joining the study. The second group is for men whose prostate cancer has come back after previous treatment, and they are now having brachytherapy (either a high-dose or pulsed-dose type) to treat the recurring cancer. For this second group, it's important that they haven't had any radiation therapy in the three months leading up to this new brachytherapy, and they shouldn't have had their prostate gland surgically removed in the past (prostatectomy).

However, some men won't be able to join the study. This includes those who have an existing autoimmune disease (where the body's immune system mistakenly attacks itself), those taking blood-thinning medicines, or those with a history of substance abuse.

Kan denna studie passa dig?

Svara på dessa snabba frågor för att se om du kan vara berättigad. Detta är endast en vägledning — forskarteamet fattar det slutgiltiga beslutet.

Are you a man aged 18 or older with prostate cancer?
Are you scheduled to have brachytherapy for your prostate cancer?
If this is your first treatment, have you had no previous prostate cancer treatments?
If your cancer has returned, have you not had any radiation in the last 3 months and not had your prostate removed?
Do you not have an autoimmune disease or take blood thinners?

Svara på varje fråga för att se ditt resultat.

Vad innebär deltagande?

If you decide to take part in this study, you will have blood samples taken at specific times: before your brachytherapy treatment begins, at some point during your treatment, and again after your treatment is finished. If your brachytherapy involves collecting tissue samples, these will also be used for the study. The exact number of visits for blood draws and the total duration of your participation will depend on your treatment schedule. You won't need to take any new medication specifically for the study. The study aims to look at how your immune system changes as a result of your standard brachytherapy treatment.

Potentiella risker och fördelar

Taking part in this study won't directly treat your cancer, as it involves collecting samples from treatments you'd be having anyway. However, the information gathered could help future patients by improving our understanding of how brachytherapy works with the immune system. The main risks involve the discomfort and small bruising from regular blood tests. As with any study, you are free to change your mind and withdraw at any time without giving a reason, and this will not affect your standard medical care.

Platser (3)

Klinik für Strahlentherapie
Verifierat postnummer
Augsburg, Tyskland· Rekryterar inte ännu
Strahlenklinik Erlangen
Verifierat postnummer
Erlangen, Tyskland· Rekrytering
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
Verifierat postnummer
München, Tyskland· Rekryterar inte ännu

Vanliga frågor

What is brachytherapy?

Brachytherapy is a type of radiation treatment for prostate cancer where small radioactive 'seeds' are placed directly into the prostate gland to kill cancer cells.

What are immune biomarkers?

These are simply signs in your blood or tissues that tell us about the activity of your body's immune system – your natural defence against disease.

Kommer deltagande i denna studie att förändra min cancerbehandling?

No, this study is observing your immune system during the brachytherapy treatment you would already be receiving. It won't change your planned cancer care.

Will I get results from my individual immune tests?

The study focuses on understanding general patterns across many patients. Individual results are usually not given back to participants.

Hur länge kommer jag att vara involverad i studien?

Your involvement depends on your brachytherapy schedule, as samples will be taken before, during, and after your treatment.

Hur du får reda på mer

Claudia Schweizer, MD

claudia.schweizer@uk-erlangen.de +49 9131 85 33968 Officiell rättegångsprotokoll

Prata alltid med din läkare eller specialist innan du bestämmer dig för att delta i en studie.

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