Chromosome 14
Last updated 17 Mar 2023
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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 14, one copy inherited from each parent, form one of the pairs. Chromosome 14 spans more than 107 million DNA building blocks (base pairs) and represents about 3.5 percent of the total DNA in cells.
Description
Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 14, one copy inherited from each parent, form one of the pairs. Chromosome 14 spans more than 107 million DNA building blocks (base pairs) and represents about 3.5 percent of the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 14 likely contains 800 to 900 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.
Conditions referring to this gene or chromosome
Further reading and references
- Chromosome 14; MedlinePlus, National Library of Medicine.
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- Falk MJ, Curtis CA, Bass NE, Zinn AB, Schwartz S. Maternal uniparental disomy chromosome 14: case report and literature review. Pediatr Neurol. 2005 Feb;32(2):116-20. doi: 10.1016/j.pediatrneurol.2004.07.007.
- Gabrea A, Leif Bergsagel P, Michael Kuehl W. Distinguishing primary and secondary translocations in multiple myeloma. DNA Repair (Amst). 2006 Sep 8;5(9-10):1225-33. doi: 10.1016/j.dnarep.2006.05.012. Epub 2006 Jul 10.
- Gilbert F. Disease genes and chromosomes: disease maps of the human genome. Chromosome 14. Genet Test. 1999;3(4):379-91. doi: 10.1089/gte.1999.3.379. No abstract available.
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- Kamnasaran D, Cox DW. Current status of human chromosome 14. J Med Genet. 2002 Feb;39(2):81-90. doi: 10.1136/jmg.39.2.81.
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- Lemire EG, Cardwell S. Unusual phenotype in partial trisomy 14. Am J Med Genet. 1999 Dec 3;87(4):294-6. doi: 10.1002/(sici)1096-8628(19991203)87:43.0.co;2-s.
- Ogata T, Kagami M, Ferguson-Smith AC. Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14. Epigenetics. 2008 Jul-Aug;3(4):181-7. doi: 10.4161/epi.3.4.6550. Epub 2008 Jul 2.
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- Schlade-Bartusiak K, Costa T, Summers AM, Nowaczyk MJ, Cox DW. FISH-mapping of telomeric 14q32 deletions: search for the cause of seizures. Am J Med Genet A. 2005 Oct 15;138A(3):218-24. doi: 10.1002/ajmg.a.30942.
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