PROP paired-like homeobox 1
Last updated 7 May 2025
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The PROP1 gene provides instructions for making a transcription factor, which is a protein that controls the activity of many other genes. The PROP1 protein is found only in the pituitary gland, which is located at the base of the brain. The pituitary gland produces and releases hormones that are needed for growth, development, and other critical body functions. The PROP1 protein helps cell types specialize (differentiate) within the pituitary gland.
Normal function
The PROP1 gene provides instructions for making a transcription factor, which is a protein that controls the activity of many other genes. The PROP1 protein is found only in the pituitary gland, which is located at the base of the brain. The pituitary gland produces and releases hormones that are needed for growth, development, and other critical body functions. The PROP1 protein helps cell types specialize (differentiate) within the pituitary gland.
Conditions referring to this gene or chromosome
Other names
homeobox protein prophet of Pit-1
pituitary-specific homeodomain factor
PROP-1
prophet of Pit1, paired-like homeodomain transcription factor
Related patient information and medicines
Patient information leaflet
Genetic testing
We all have 46 chromosomes in our cells. Chromosomes are made from DNA (deoxyribonucleic acid). Genes are short sections of DNA and each chromosome contains hundreds to thousands of genes. Genes contain the information our bodies need to make chemicals called proteins. Proteins form the structure of our bodies and play an important role in the.
Patient information leaflet
Jellyfish sting
What are jellyfish. Jellyfish are soft-bodied free-swimming animals with a jelly-like umbrella-shaped bell and trailing tentacles. The tentacles are covered in tiny sacs (called nematocysts) which release venom. A few live in fresh water, some in shallow coastal waters, and some in the deep oceans. They are believed to be the oldest multi-organ.
Patient information leaflet
Amniocentesis
The most common reason for a pregnant woman to be offered amniocentesis is to see if her developing baby has a chromosomal disorder such as Down's syndrome. A note about DNA, genes and chromosomes In most cells of your body you have 46 chromosomes arranged in 23 pairs. 22 of the pairs are matching pairs. The 23rd pair are the sex chromosomes,.
Patient information leaflet
Cri du chat syndrome
Cri du chat syndrome is a chromosome problem caused by a missing piece of chromosome 5. The syndrome is called cri du chat (French for cry of the cat) because affected babies often have a high-pitched cry. Not all babies with the missing piece of chromosome 5 will develop cri du chat syndrome. Cri du chat syndrome may cause a variety of.
Patient information leaflet
Travelling to remote locations
These include Zika virus , malaria , most viral haemorrhagic fevers, schistosomiasis , HIV , sleeping sickness, and leishmaniasis. Visit the Travel Health Pro website (see under 'Further Reading and References' below) for country-specific advice and to understand how you may minimise your risk of exposure to any or all of these. The risk of.
Patient information leaflet
Medicines to keep at home
Minor illness and mild aches or pains are common. It is useful to keep a few medicines at home in case you need something when you can't get to a pharmacy, or they are closed. Always read the labels carefully and follow the instructions, and store the medicines out of the reach of children. Your pharmacist is a good person to give you more.
Further reading and references
- PROP paired-like homeobox 1; MedlinePlus, National Library of Medicine.
- Bottner A, Keller E, Kratzsch J, Stobbe H, Weigel JF, Keller A, Hirsch W, Kiess W, Blum WF, Pfaffle RW. PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis. J Clin Endocrinol Metab. 2004 Oct;89(10):5256-65. doi: 10.1210/jc.2004-0661.
- Carvalho LR, Nishi MY, Correa FA, Moreira Marques J, Arnhold IJP, Mendonca BB. PROP1-Related Combined Pituitary Hormone Deficiency. 2000 Dec 7 [updated 2022 Feb 24]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1347/
- Dusatkova P, Pfaffle R, Brown MR, Akulevich N, Arnhold IJ, Kalina MA, Kot K, Krzisnik C, Lemos MC, Malikova J, Navardauskaite R, Obermannova B, Pribilincova Z, Sallai A, Stipancic G, Verkauskiene R, Cinek O, Blum WF, Parks JS, Austerlitz F, Lebl J. Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations. Eur J Hum Genet. 2016 Mar;24(3):415-20. doi: 10.1038/ejhg.2015.126. Epub 2015 Jun 10.
- Kelberman D, Rizzoti K, Lovell-Badge R, Robinson IC, Dattani MT. Genetic regulation of pituitary gland development in human and mouse. Endocr Rev. 2009 Dec;30(7):790-829. doi: 10.1210/er.2009-0008. Epub 2009 Oct 16.
- Kelberman D, Turton JP, Woods KS, Mehta A, Al-Khawari M, Greening J, Swift PG, Otonkoski T, Rhodes SJ, Dattani MT. Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD). Clin Endocrinol (Oxf). 2009 Jan;70(1):96-103. doi: 10.1111/j.1365-2265.2008.03326.x. Epub 2008 Jun 25.
- Lemos MC, Gomes L, Bastos M, Leite V, Limbert E, Carvalho D, Bacelar C, Monteiro M, Fonseca F, Agapito A, Castro JJ, Regateiro FJ, Carvalheiro M. PROP1 gene analysis in Portuguese patients with combined pituitary hormone deficiency. Clin Endocrinol (Oxf). 2006 Oct;65(4):479-85. doi: 10.1111/j.1365-2265.2006.02617.x.
- Mody S, Brown MR, Parks JS. The spectrum of hypopituitarism caused by PROP1 mutations. Best Pract Res Clin Endocrinol Metab. 2002 Sep;16(3):421-31. doi: 10.1053/beem.2002.0218.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.