TNF receptor superfamily member 1A

Normal function

The TNFRSF1A gene provides instructions for making a protein called tumour necrosis factor receptor 1 (TNFR1). This protein is found spanning the membrane of cells, with part of the TNFR1 protein outside the cell and part of the protein inside the cell. Outside the cell, the TNFR1 protein attaches (binds) to another protein called tumour necrosis factor (TNF). The interaction of the TNF protein with the TNFR1 protein causes the TNFR1 protein to bind to two other TNFR1 proteins, forming a three-protein complex called a trimer. This trimer formation is necessary for the TNFR1 protein to be functional.

The binding of the TNF and TNFR1 proteins causes the TNFR1 protein to send signals inside the cell. Signaling from the TNFR1 protein can trigger either inflammation or self-destruction of the cell (apoptosis). Signaling within the cell initiates a pathway that turns on a protein called nuclear factor kappa B, which triggers inflammation and leads to the production of immune system proteins called cytokines. Apoptosis is initiated when the TNFR1 protein, bound to the TNF protein, is brought into the cell and starts a process known as the caspase cascade.

Conditions referring to this gene or chromosome

• Tumour necrosis factor receptor-associated periodic syndrome

• Multiple sclerosis

Other names

p55

p55-R

TNF-R

TNF-R1

TNF-R55

TNFR-I

TNFR1

TNFR55

TNR1A_HUMAN

tumour necrosis factor binding protein 1

tumour necrosis factor receptor superfamily member 1A

tumour necrosis factor receptor superfamily, member 1A

tumour necrosis factor receptor type 1

tumour necrosis factor-alpha receptor