three prime repair exonuclease 1
Last updated 26 Sept 2024
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The TREX1 gene provides instructions for making the three prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means that it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends.
Normal function
The TREX1 gene provides instructions for making the three prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means that it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends.
The three prime repair exonuclease 1 enzyme is helps remove incorrect or damaged nucleotides from DNA. These DNA fragments are created during cell division, DNA repair, cell death (apoptosis), and other processes. The removal of these nucleotides creates even DNA ends, which are necessary for maintaining the stability of genetic material.
Unusual pieces of DNA may be mistaken by cells for the genetic material of viral invaders, triggering immune system reactions. The three prime repair exonuclease 1 enzyme removes pieces of DNA that might otherwise set off an immune response.
Conditions referring to this gene or chromosome
Other names
3' repair exonuclease 1
3'-5' exonuclease TREX1
deoxyribonuclease III, dnaQ/mutD-like
DNase III
DRN3
TREX1_HUMAN
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Further reading and references
- three prime repair exonuclease 1; MedlinePlus, National Library of Medicine.
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