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Chlorambucil-tabletter

Chlorambucil is used to treat a number of different cancers of the blood or lymphatic system.

Keep your regular appointments with your doctor or hospital. You will need to have frequent blood tests and check-ups.

The most common side-effects are feeling sick (nausea), diarrhoea and mouth ulcers.

Överblick

  • Chlorambucil is a chemotherapy medicine used to treat some cancers, including blood and lymphatic system cancers.

  • It prevents cancer cells from growing and dividing.

  • Take tablets on an empty stomach, either an hour before food or three hours after.

  • Do not break, crush or chew the tablets.

  • Chlorambucil can lower your white blood cell count, increasing infection risk.

  • Discuss suitable contraception with your doctor as pregnancy should be avoided.

  • Seek medical advice if you experience unexpected bruising, bleeding, fever, or signs of infection.

About chlorambucil

Typ av medicin

An alkylating chemotherapy medicine

Används för

Treatment of cancer

Tillgänglig som

Tablet

Chlorambucil is used to treat some cancers, particularly cancer of white blood cells and cancers of the lymphatic system. It can be prescribed both for adults and for children.

In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines (chemotherapy) like chlorambucil work by preventing the growth and division of cells, and this reduces the number of cancer cells your body makes. Chlorambucil can be used as a treatment on its own, or alongside other medicines to help treat your condition.

Before taking chlorambucil

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or, if appropriate, your child) start taking chlorambucil it is important that your doctor or pharmacist knows:

  • Om du är gravid eller ammar.

  • If you have any problems with the way your liver works.

  • If you have a kidney problem called nephrotic syndrome.

  • If you have ever had a fit (seizure) or if you have epilepsy.

  • If you have an infection or feel unwell.

  • Om du har en sällsynt ärftlig blodsjukdom som kallas porfyri.

  • Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

How to take chlorambucil

  • Before you start this treatment, read any printed information you have been given by your doctor and the leaflet from inside your pack of tablets. The leaflet will give you more information about chlorambucil and a full list of side-effects which you may experience from taking it.

  • Chlorambucil will be given to you by a specialist doctor who is experienced in treating your condition. Your doctor will calculate what dose is right for you and will tell you how many tablets to take each day - it is important that you take chlorambucil exactly as you have been told. Your dose will also be printed on the label of your pack. If you are unsure about what to do, or if you have any other concerns, you should contact your doctor or hospital clinic for advice.

  • You should take the tablets when your stomach is empty, which means taking them one hour before eating food, or waiting until three hours afterwards. This is because food prevents chlorambucil from being absorbed by your body, which means the medicine is much less effective for you.

  • Swallow the tablets with a drink of water. Do not break, crush or chew them.

  • Try to take chlorambucil at the same time each day, as this will help you to remember to take your doses.

  • If you are sick shortly after taking a dose, or if you forget a dose, contact your doctor or clinic for advice on what to do. You will be told whether to take the dose again, or to wait until the next dose is due.

Få ut det mesta av din behandling

  • You must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment.

  • Chlorambucil lowers the number of white cells in your blood, increasing the chance of you getting an infection. You should take certain precautions to reduce the risk of infection - if possible, avoid people with infections and let your doctor know if you think you are getting a sore throat or if you have a high temperature (fever).

  • It is important that you do not get pregnant or father a child while you are taking chlorambucil. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

  • If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking chlorambucil. There is a risk of reduced fertility after treatment with chlorambucil.

  • This medicine lowers your natural protection against infections. It is important to protect yourself from serious illness by having any vaccinations your doctor offers you. If you live with other people they can also help protect you by having their vaccinations when invited.

  • Some vaccines may not be suitable for people with lowered immune systems. Always let the person vaccinating know that you are taking this medicine.

  • Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.

Can chlorambucil cause problems?

Along with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with chlorambucil, your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones associated with chlorambucil. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your tablets.

Common

chlorambucil side-effects - these affect fewer than 1 in 10 people who take this medicine

Vad kan jag göra om jag upplever detta?

Feeling sick (nausea) or being sick (vomiting)

Stick to simple foods. Let your doctor know about this, as an anti-sickness medicine may help

Diarré

Drink plenty of water to replace lost fluids. If this continues, speak with your doctor

Munsår

Brushing your teeth 2-3 times a day with a soft toothbrush and regularly using a mouth rinse may help to prevent this. If mouth ulcers become a problem, speak with your doctor

Less common but more serious

chlorambucil side-effects


Vad kan jag göra om jag upplever detta?

Unexpected bruising or bleeding, a high temperature (fever), or symptoms of an infection

Let your doctor know about this straightaway

Skin rash

Let your doctor know about this as soon as possible. Some skin rashes can be a sign of an allergic-type reaction

Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.

How to store chlorambucil

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Store the tablets in a refrigerator.

  • Return any unused or unwanted tablets to your pharmacy to destroy. These will need special disposal.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

symptomkontroll

Osäker på att blanda mediciner?

Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.

Vanliga frågor

What should I do if I accidentally miss a dose of chlorambucil?

If you miss a dose of chlorambucil, or if you are sick shortly after taking a dose, you should contact your doctor or clinic for advice. They will tell you whether to take the dose again or to wait for your next scheduled dose.

How do I care for my mouth if I develop mouth ulcers while taking chlorambucil?

If you experience mouth ulcers, brushing your teeth 2-3 times a day with a soft toothbrush and using a mouth rinse regularly can help. If the mouth ulcers become bothersome or do not improve, you should speak with your doctor for further advice.

Are there any specific foods or drinks I should avoid while on chlorambucil treatment?

The article states that food prevents chlorambucil from being absorbed properly, making the medicine less effective. Therefore, you should take the tablets on an empty stomach: one hour before eating or three hours after eating. There are no other specific food or drink restrictions mentioned beyond this advice for absorption.

Can I receive vaccinations while I am being treated with chlorambucil?

You should discuss any vaccinations with your doctor, as some may not be suitable for people with lowered immune systems due to chlorambucil. It is important to inform the person giving the vaccination that you are taking this medicine.

What is the proper way to dispose of any leftover or expired chlorambucil tablets?

Any unused or unwanted chlorambucil tablets should be returned to your local pharmacy for proper disposal. This is important as they require special handling.

Vidare läsning och referenser

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • Nästa granskning: 18 jun 2027
  • 19 dec 2022 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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