Chlorambucil tablets
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 19 dec 2022
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Chlorambucil is used to treat a number of different cancers of the blood or lymphatic system.
Keep your regular appointments with your doctor or hospital. You will need to have frequent blood tests and check-ups.
The most common side-effects are feeling sick (nausea), diarrhoea and mouth ulcers.
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About chlorambucil
Typ av medicin | An alkylating chemotherapy medicine |
Används för | Treatment of cancer |
Tillgänglig som | Tablet |
Chlorambucil is used to treat some cancers, particularly cancer of white blood cells and cancers of the lymphatic system. It can be prescribed both for adults and for children.
In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines (chemotherapy) like chlorambucil work by preventing the growth and division of cells, and this reduces the number of cancer cells your body makes. Chlorambucil can be used as a treatment on its own, or alongside other medicines to help treat your condition.
Before taking chlorambucil
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or, if appropriate, your child) start taking chlorambucil it is important that your doctor or pharmacist knows:
Om du är gravid eller ammar.
If you have any problems with the way your liver works.
If you have a kidney problem called nephrotic syndrome.
If you have ever had a fit (seizure) or if you have epilepsy.
If you have an infection or feel unwell.
If you have a rare inherited blood disorder called porphyria.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
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How to take chlorambucil
Tillbaka till innehållBefore you start this treatment, read any printed information you have been given by your doctor and the leaflet from inside your pack of tablets. The leaflet will give you more information about chlorambucil and a full list of side-effects which you may experience from taking it.
Chlorambucil will be given to you by a specialist doctor who is experienced in treating your condition. Your doctor will calculate what dose is right for you and will tell you how many tablets to take each day - it is important that you take chlorambucil exactly as you have been told. Your dose will also be printed on the label of your pack. If you are unsure about what to do, or if you have any other concerns, you should contact your doctor or hospital clinic for advice.
You should take the tablets when your stomach is empty, which means taking them one hour before eating food, or waiting until three hours afterwards. This is because food prevents chlorambucil from being absorbed by your body, which means the medicine is much less effective for you.
Swallow the tablets with a drink of water. Do not break, crush or chew them.
Try to take chlorambucil at the same time each day, as this will help you to remember to take your doses.
If you are sick shortly after taking a dose, or if you forget a dose, contact your doctor or clinic for advice on what to do. You will be told whether to take the dose again, or to wait until the next dose is due.
Få ut det mesta av din behandling
Tillbaka till innehållYou must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment.
Chlorambucil lowers the number of white cells in your blood, increasing the chance of you getting an infection. You should take certain precautions to reduce the risk of infection - if possible, avoid people with infections and let your doctor know if you think you are getting a sore throat or if you have a high temperature (fever).
It is important that you do not get pregnant or father a child while you are taking chlorambucil. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.
If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking chlorambucil. There is a risk of reduced fertility after treatment with chlorambucil.
This medicine lowers your natural protection against infections. It is important to protect yourself from serious illness by having any vaccinations your doctor offers you. If you live with other people they can also help protect you by having their vaccinations when invited.
Some vaccines may not be suitable for people with lowered immune systems. Always let the person vaccinating know that you are taking this medicine.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
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Can chlorambucil cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with chlorambucil, your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones associated with chlorambucil. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your tablets.
Common chlorambucil side-effects - these affect fewer than 1 in 10 people who take this medicine | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting) | Stick to simple foods. Let your doctor know about this, as an anti-sickness medicine may help |
Diarré | Drink plenty of water to replace lost fluids. If this continues, speak with your doctor |
Mouth ulcers | Brushing your teeth 2-3 times a day with a soft toothbrush and regularly using a mouth rinse may help to prevent this. If mouth ulcers become a problem, speak with your doctor |
Less common but more serious chlorambucil side-effects | Vad kan jag göra om jag upplever detta? |
Unexpected bruising or bleeding, a high temperature (fever), or symptoms of an infection | Let your doctor know about this straightaway |
Skin rash | Let your doctor know about this as soon as possible. Some skin rashes can be a sign of an allergic-type reaction |
Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.
How to store chlorambucil
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Store the tablets in a refrigerator.
Return any unused or unwanted tablets to your pharmacy to destroy. These will need special disposal.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vidare läsning och referenser
- Manufacturer's PIL, Chlorambucil 2 mg tablets; Aspen Pharma Trading Ltd, The electronic Medicines Compendium. Dated January 2017.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Nästa granskning: 18 jun 2027
19 dec 2022 | Senaste versionen

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