Ethosuximide for epilepsy
Emeside, Epesri
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 10 Jan 2024
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Take ethosuximide regularly. Most people are prescribed two doses a day.
Do not stop taking it unless your doctor tells you to.
Ethosuximide may make you feel sick (nausea) when you first start taking it. This should soon settle down.
At a glance
Ethosuximide is an epileptic medicine used to treat absence seizures, mainly in children and young people.
It helps reduce seizures by stabilising abnormal electrical activity in the brain.
Take ethosuximide exactly as your doctor tells you, usually twice a day.
Do not stop taking ethosuximide suddenly, as this can cause problems.
Common side-effects include feeling sick, headache, dizziness, and tiredness.
Contact your doctor if you experience a high temperature, mouth ulcers, bruising, or bleeding.
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About ethosuximide
Typ av medicin | An antiepileptic medicine |
Används för | Epilepsy with absence seizures |
Även kallad | Emeside®, Epesri® |
Tillgänglig som | Capsules and oral liquid medicine |
Absence seizures are a form of epilepsy. They mainly occur in children and young people. Absence seizures are a brief loss of consciousness (an 'absence') for a few seconds, and can appear like daydreaming. Although no underlying cause for this type of seizure can be found, it is thought that the brain develops a low threshold for bursts of abnormal electrical activity. Ethosuximide is one of the medicines commonly prescribed for this type of epilepsy. It helps to reduce absence seizures by stabilising the abnormal electrical activity in the brain.
Ethosuximide is occasionally prescribed for some other types of seizures.
Before taking ethosuximide
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if you are the carer) start taking ethosuximide it is important that your doctor knows:
Om du är gravid, försöker bli gravid eller ammar.
If you have any problems with the way your kidneys work, or with the way your liver works.
If you have a rare inherited blood disorder called porphyria.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
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How to take ethosuximide
Tillbaka till innehållBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ethosuximide and will provide you with a full list of the side-effects which you may experience from taking it.
Take ethosuximide exactly as your doctor tells you to. Your dose will be printed on the label of the pack of medicine to remind you about what the doctor said. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. It is usual to take two doses each day. Doses for children are tailored to their age and weight.
Try to take your doses at the same times of day, each day. Having a routine will help you to remember to take your doses regularly. You can take ethosuximide either before or after meals. If you are taking capsules, swallow them with a drink of water.
If you (or your child) have been given ethosuximide oral liquid medicine, remember to shake the bottle well before you measure out the dose. It is also a good idea to brush your (or your child's) teeth after each dose as the medicine contains sugar.
If you forget to take a dose, take it as soon as you remember, unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Tillbaka till innehållWhen you first start a new treatment for epilepsy there may be a change in the number or type of seizures you experience. Your doctor will advise you about this.
Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
Different formulations and makes of ethosuximide can act in a slightly different way in your body. Because of this, your doctor may recommend that you continue to take ethosuximide from the same manufacturer each time you obtain a new supply. If so, each time you collect a prescription, check to make sure your supply looks the same and that the name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to advise you.
If you buy any medicines, check with a pharmacist that they are suitable for you to take.
While you are being treated for epilepsy there is a small risk that you may develop mood changes, distressing thoughts and feelings about suicide. If this happens, you must tell your doctor about it straightaway.
People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to start driving again. This will usually be after a year free of seizures.
Antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.
You need to take ethosuximide regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.
If you drink alcohol, ask your doctor for advice. Your doctor may advise you not to drink alcohol while you are on this medicine.
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Can ethosuximide cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with ethosuximide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common ethosuximide side-effects (these affect less than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting), tummy (abdominal) discomfort | Try to stick to simple meals - avoid rich or spicy foods |
Huvudvärk | Drick mycket vatten och be din apotekare rekommendera en lämplig smärtstillande. Om huvudvärken fortsätter, informera din läkare |
Feeling dizzy, tired or sleepy | If this happens, do not drive and do not use tools or machines |
Diarré | Drick mycket vatten för att ersätta de förlorade vätskorna |
Lack of appetite, feeling unsteady, itchy skin rash, mood changes | If any of these become troublesome, speak with your doctor for advice |
Viktigt: your doctor will discuss with you the possibility that ethosuximide can cause blood disorders. Although these occur less commonly than the side-effects listed above, it is important that you contact your doctor omedelbart if you experience any of the following symptoms:
A high temperature (fever).
Mouth ulcers.
Unexplained bruising or bleeding.
If you experience any other symptoms which you think may be due to ethosuximide, speak with your doctor or pharmacist for further advice.
How to store ethosuximide
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
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Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
What is an absence seizure and who is typically affected?
Absence seizures are a type of epilepsy where a person briefly loses consciousness for a few seconds, appearing as if they are daydreaming. They mainly occur in children and young people.
Why is ethosuximide prescribed for absence seizures?
Ethosuximide is commonly prescribed to help reduce absence seizures by stabilising the abnormal electrical activity in the brain that causes them. It can also be occasionally used for some other types of seizures.
Are there specific things I need to tell my doctor before starting ethosuximide, especially if it's for my child?
Yes, it's important to tell your doctor if you or your child are pregnant, trying for a baby, or breastfeeding, if there are any kidney or liver problems, if you have porphyria (a rare inherited blood disorder), if you are taking any other medicines (including non-prescription or herbal ones), or if you have a history of allergic reactions to medicines.
What should I do if I forget to give a dose of ethosuximide?
If you forget a dose, give it as soon as you remember, unless it's almost time for the next dose. In that case, skip the missed dose and continue with the regular schedule. Do not give two doses together to make up for a forgotten one.
Are there any special instructions for giving ethosuximide oral liquid medicine?
Yes, if you are giving the oral liquid, remember to shake the bottle well before measuring the dose. It's also a good idea to brush your or your child's teeth after each dose because the medicine contains sugar.
What is the advice about driving for someone taking ethosuximide for epilepsy?
People with epilepsy must stop driving initially. Your doctor will advise you when it might be possible to start driving again, which is usually after a year free of seizures.
What should I do if I experience mood changes or distressing thoughts while taking ethosuximide?
There is a small risk of developing mood changes, distressing thoughts, or feelings about suicide when being treated for epilepsy. If this happens, you must tell your doctor about it straight away.
What are some common side effects of ethosuximide and what can I do about them?
Common side effects, affecting less than 1 in 10 people, include feeling sick or being sick, tummy discomfort, headache, feeling dizzy, tired, sleepy, diarrhoea, lack of appetite, feeling unsteady, itchy skin rash, and mood changes. For tummy issues, try simple meals. For headaches, drink water and ask a pharmacist about painkillers. If dizzy or tired, do not drive or operate machinery. For diarrhoea, drink plenty of water. If any of these become troublesome, or if you experience other symptoms you think are due to the medicine, speak with your doctor or pharmacist.
Are there any serious symptoms I should watch out for that might indicate a problem with my blood?
While less common, ethosuximide can cause blood disorders. You should contact your doctor straight away if you experience a high temperature (fever), mouth ulcers, or unexplained bruising or bleeding, as these could be signs of a blood disorder.
Vidare läsning och referenser
- Manufacturer's PIL, Ethosuximide 250 mg/5 ml Syrup; Essential Pharma Ltd, The electronic Medicines Compendium. Dated May 2023.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 9 Jan 2027
10 Jan 2024 | Senaste versionen

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