Letrozol för bröstcancer
Femara
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 17 feb 2023
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Take one 2.5 mg letrozole tablet every day. Swallow the tablet with a drink of water.
The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. These can occur in more than 1 in 10 women who take letrozole.
Överblick
Letrozole is a hormone treatment for breast cancer in women who have been through menopause.
It works by reducing the amount of oestrogen in the body, which slows cancer cell growth.
Take one tablet daily at the same time each day, with or without food.
Inform your doctor if you have kidney or liver problems, osteoporosis, or are taking other medicines.
Common side effects include hot flushes, headaches, muscle pain, and tiredness.
Regular bone density tests are needed as letrozole can reduce bone strength.
About letrozole
Typ av medicin | An aromatase inhibitor hormone antagonist |
Används för | Breast cancer in women |
Även kallad | Femara® |
Tillgänglig som | Tabletter |
Letrozole is a hormonal bröstcancer treatment.
Some breast cancers need the hormone oestrogen to grow. In women who have been through the menopause, the main source of oestrogen is through the change of sex hormones, called androgens, into oestrogen. An enzyme called 'aromatase' is needed for this change to occur. Letrozole works by blocking (inhibiting) this enzyme. This reduces the amount of oestrogen in your body, which slows the growth of the cancer cells.
Before taking letrozole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking letrozole it is important that your doctor knows:
If you have not yet gone through the menopause, or if there is a possibility you could be pregnant.
If you have any problems with the way your liver works, or any problems with the way your kidneys work.
If you have a loss of bone density, or 'brittle bones' - a condition known as osteoporosis.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to take letrozole
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about letrozole and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take one 2.5 mg tablet of letrozole each day, exactly as your doctor tells you to.
You can take letrozole at whatever time of day you find easiest to remember, but try to take your doses at the same time of day each day. This will help you to remember to take letrozole regularly.
Swallow the tablet with a drink of water. You can take letrozole either with or without food.
If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses on the same day to make up for a missed dose.
Continue to take the tablets regularly each day until your doctor tells you otherwise. You may need to take letrozole for a number of years.
Få ut det mesta av din behandling
Try to keep your regular appointments with your doctor and clinic. This is so your doctor can check on your progress. Letrozole lowers the levels of female hormones in your body, which can reduce the strength of your bones. You will need to have bone density tests to check for this before and during your treatment.
If you are due to have an operation or any dental treatment, tell the person carrying out the treatment that you are taking letrozole.
If you buy any medicines 'over the counter', check with a pharmacist that they are safe to take with your prescribed medicines.
Can letrozole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with letrozole. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following become troublesome.
Very common letrozole side-effects (these affect more than 1 in 10 women) | Vad kan jag göra om jag upplever detta? |
Hot flushes, increased sweating | Try to keep cool by wearing light, airy clothes |
Headache, muscle or joint pain | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If it continues, let your doctor know |
Feeling tired, weak or dizzy | Kör inte och använd inte verktyg eller maskiner när du är påverkad |
High blood levels of cholesterol | Your doctor will arrange for you to have tests to check for this |
If you experience other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
How to store letrozole
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
Is letrozole a form of chemotherapy?
No, letrozole is not a chemotherapy drug. It is a hormonal breast cancer treatment classified as an aromatase inhibitor hormone antagonist. It works by reducing oestrogen in the body, whereas chemotherapy typically works by directly killing cancer cells.
How does letrozole affect my body to treat breast cancer?
Letrozole works by blocking an enzyme called 'aromatase'. In women who have gone through menopause, this enzyme is responsible for converting sex hormones (androgens) into oestrogen. Some breast cancers need oestrogen to grow, so by reducing the amount of oestrogen in your body, letrozole slows the growth of these cancer cells.
What should I do if I accidentally take two doses of letrozole instead of one?
The article states to never take more than the prescribed dose. If you suspect you or someone else has taken an overdose, you should go to the accident and emergency department of your local hospital immediately and take the medicine container with you. Do not try to manage it yourself at home.
How long will I need to continue taking letrozole?
You should continue to take letrozole regularly each day until your doctor tells you otherwise. The article mentions that you may need to take it for a number of years.
What should I do if I'm planning to have surgery or dental work while taking letrozole?
If you are scheduled for an operation or any dental treatment, it is important to inform the person carrying out the treatment that you are currently taking letrozole. This allows them to consider your medication in your treatment plan.
Vidare läsning och referenser
- Manufacturer's PIL, Femara® 2.5 mg Tablets; Novartis Pharmaceuticals UK Ltd, The electronic Medicines Compendium. Dated April 2021.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
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Next review due: 16 Aug 2027
17 feb 2023 | Senaste versionen

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