Mefenamic acid for pain and inflammation

About mefenamic acid

Anti-inflammatoriska smärtstillande medel like mefenamic acid are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Mefenamic acid is used to treat painful conditions such as arthritis, pain associated with heavy menstrual bleeding, and pain after surgical operations.

Mefenamic acid works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking mefenamic acid, it is important that your doctor knows:

• Om du någonsin har haft ett magsår eller duodenalsår, eller om du har en inflammatorisk tarmsjukdom som Crohns sjukdom eller ulcerös kolit.

• Om du har astma eller någon annan allergisk sjukdom.

• Om du är gravid, försöker bli gravid eller ammar.

• Om du har några problem med hur din lever fungerar, eller om du har några problem med hur dina njurar fungerar.

• If you have a heart condition or a problem with your blood vessels or circulation.

• Om du har högt blodtryck.

• If you have any blood clotting problems.

• If you have epilepsy.

• Om du har högt blodsocker eller kolesterolnivåer.

• Om du har en bindvävssjukdom som systemisk lupus erythematosus. Detta är ett inflammatoriskt tillstånd som också kallas lupus eller SLE.

• If you have a rare inherited blood disorder called porphyria.

• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as as herbal and complementary medicines.

• Om du någonsin har haft en allergisk reaktion mot någon annan NSAID (såsom aspirin, ibuprofen, diklofenak och indometacin), eller mot något annat läkemedel.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about mefenamic acid, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take mefenamic acid exactly as your doctor tells you to. The usual dose is 500 mg, which is taken as two 250 mg capsules, or one 500 mg tablet. You will be asked to take this dose three times a day. If you are taking it for period pain, your doctor will likely suggest that you take it for a few days each month, starting on your first day of bleeding.

• Take mefenamic acid with food. This will help to protect your stomach from side-effects such as indigestion.

• If you forget to take a dose, take it as soon as you remember unless your next dose is due. If your next dose is due, then take the dose which is due but leave out the forgotten one. Do not take two doses together to make up for a missed dose.

• Your doctor will try to prescribe you mefenamic acid for the shortest time possible to reduce the risk of side-effects. If you need to take it over a long period of time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.

• Try to keep any regular appointments with your doctor. This is so your doctor can check on your progress. It is especially important if you are taking mefenamic acid for a long-term condition.

• If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories. If this happens to you, you should stop taking mefenamic acid and see your doctor as soon as possible.

• Det är känt att det finns en liten ökad risk för hjärt- och kärlproblem hos personer som tar vissa antiinflammatoriska smärtstillande medel under lång tid. Din läkare kommer att förklara detta för dig och kommer att ordinera den lägsta lämpliga dosen för den kortaste tiden för att minska risken. Ta inte mer än den rekommenderade dosen.

• If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because you should not take mefenamic acid with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought 'over the counter'.

• Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with mefenamic acid. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Viktigt: if you experience any of the following less common but possibly serious symptoms, stop taking mefenamic acid and contact your doctor for advice straightaway:

• Om du har några andningssvårigheter som väsande andning eller andfåddhet.

• If you have any signs of an allergic reaction such as swelling around your mouth or face, or an itchy skin rash.

• If you pass blood or black stools, bring up (vomit) blood, or have severe stomach pains.

Om du upplever några andra symtom som du tror kan bero på medicinen, tala med din läkare eller apotekare för vidare råd.

• Förvara alla läkemedel utom räckhåll och synhåll för barn.

• Förvara på en sval, torr plats, borta från direkt värme och ljus.