Melphalan tablets
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 17 aug 2024
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Melphalan will be prescribed for you by a specialist doctor.
Keep your regular appointments with your doctor or hospital. You will need to have frequent blood tests.
If you think you are getting an infection or if you have a high temperature, please contact your doctor straightaway.
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About melphalan tablets
Typ av medicin | An alkylating chemotherapy medicine |
Används för | Multiple myeloma; polycythaemia vera |
Tillgänglig som | Tabletter |
Melphalan is used to treat some cancers and conditions where cells in the body rapidly divide and multiply. It is most commonly prescribed for conditions such as multiple myeloma och polycythaemia vera. Multiple myeloma is a cancer of the bone marrow. Polycythaemia vera is a bone marrow disease that leads to an abnormal increase in the number of red blood cells in the body. It makes your blood 'thicker' and can make you feel dizzy and short of breath.
In these conditions, certain cells in the body grow and multiply too fast. Melphalan works by preventing cells from multiplying. This reduces the number of cancer cells or unwanted blood cells.
Before taking melphalan
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking melphalan it is important that your doctor knows:
Om du är gravid eller ammar.
Om du har några problem med hur dina njurar fungerar.
If you have an infection or feel unwell.
If you have a rare inherited blood condition called porphyria.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
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How to take melphalan
Tillbaka till innehållBefore you start this treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet from inside your pack of tablets. These will give you more information about melphalan and will provide you with a full list of the side-effects which you may experience from taking it.
Melphalan will be prescribed for you by a specialist doctor who is experienced in treating your condition. Your doctor will calculate what dose is right for you and will tell you how to take it. The dose you are prescribed will depend upon the reason why you are taking it, so it is important that you take the tablets exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said to you but if you are unsure about how to take the tablets, or if you have any other concerns, you should contact your doctor or hospital clinic for advice.
Swallow melphalan tablets whole with a drink of water. Do not break, crush or chew the tablets before you swallow.
If you are sick shortly after taking a dose, or if you forget to take a dose at the correct time, contact your doctor or clinic for advice on what to do.
Få ut det mesta av din behandling
Tillbaka till innehållYou must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment with melphalan.
It is important that you do not get pregnant or father a child while you are taking melphalan. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you would like to have children in the future, you should ask your doctor for advice about family planning before you begin taking melphalan. This is particularly important if you are a man, as there is a risk of reduced male fertility or sterility with melphalan treatment.
While you are taking melphalan and for six months after you have stopped the treatment, do not have any immunisations (vaccinations) without talking with your specialist doctor first. Melphalan lowers your body's resistance and there is a risk that you will get an infection from some vaccines.
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Can melphalan cause problems?
Tillbaka till innehållMedicines used to treat cancer can have a number of side-effects, some of which can be delayed for several days or weeks after taking the medicine. Most chemotherapy medicines can lower the number of white cells in your blood, which increases the risk of you getting an infection. While you are taking melphalan you should take precautions to reduce the risk of getting an infection - you can do this by avoiding being with people who you know have an infection. If you think you are getting a sore throat or if you have a high temperature, please let your doctor know as soon as possible so that you can get some treatment straightaway.
Your doctor will discuss with you the possibility of unwanted side-effects from your treatment with melphalan, although not everyone experiences these. The table below contains some of the side-effects associated with melphalan. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Please let your doctor know if you experience any of the following:
Very common melphalan side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
A high temperature, or symptoms of an infection | Let your doctor know about this straightaway |
Feeling sick (nausea) or being sick (vomiting) | Stick to simple foods. Let your doctor know about this, as you can be given an anti-sickness medicine |
Diarré | Drink plenty of water to replace lost fluids. If this continues, speak with your doctor |
Common melphalan side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Mouth ulcers | Brushing your teeth 2-3 times a day with a soft toothbrush and regularly using a mouth rinse may help to prevent this. If mouth ulcers become a problem, speak with your doctor |
Raised levels of urea in your blood | Your doctor will check for this |
Hair loss | This is not permanent but speak with your doctor if you are concerned about it |
If you experience any other symptoms which you think may be due to the tablets, please speak with your doctor or pharmacist for further advice.
How to store melphalan
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Melphalan tablets should be stored in a refrigerator at 2°C to 8°C and kept dry.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your prescribed medicines.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vidare läsning och referenser
- Manufacturer's PIL, Melphalan 2 mg Tablets; Aspen, The electronic Medicines Compendium. Dated April 2024.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 21 Aug 2027
17 aug 2024 | Senaste versionen

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