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Nortriptyline tablets

Keep your regular appointments with your doctor. This is so your doctor can check on your progress.

The tablets could make you feel sleepy. If this happens, do not drive and do not use tools or machines. Do not drink alcohol.

Tell your doctor if you experience any troublesome side-effects.

At a glance

  • Nortriptyline is a medicine used to treat depression, and sometimes nerve pain.

  • It is available as tablets, capsules, and an oral liquid.

  • Take your dose as prescribed by your doctor, usually multiple times a day or once at bedtime.

  • It can take 4-6 weeks to feel the full benefit when treating depression.

  • Common side-effects include dry mouth, constipation, and feeling sleepy.

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About nortriptyline

Typ av medicin

A tricyclic antidepressant

Används för

Treatment of depression

Tillgänglig som

Tablets, capsules and oral liquid medicine

Nortriptyline belongs to a group of medicines known as tricyclic antidepressants. It is prescribed for the treatment of depression. Depression can develop for no apparent reason, or it may be triggered by a life event such as a relationship problem, bereavement, or illness. People with depression have a consistently low mood and other symptoms severe enough to interfere with normal day-to-day activities.

Nortriptyline is thought to work by interfering with certain brain chemicals (called neurotransmitters) which may be involved in causing the symptoms of depression.

Although nortriptyline is only licensed for use in depression, it is also commonly prescribed to help ease certain types of nerve pain. If you have been prescribed nortriptyline for this reason, then you should ask your doctor if you have any questions about your treatment.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking nortriptyline it is important that your doctor knows:

  • Om du är gravid eller ammar.

  • If you have an overactive thyroid gland.

  • If you have a problem with the way your liver works.

  • If you have epilepsy.

  • If you have high blood sugar levels (diabetes mellitus).

  • If you have had problems with constipation.

  • If you have any difficulties passing urine, or if you have had prostate trouble.

  • If you have a heart disorder or blood vessel disease.

  • If you have ever had a mental health problem (in particular, bipolar disorder or psychosis).

  • If you have increased pressure in your eyes, a condition called glaucoma.

  • If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.

  • If you have a rare inherited blood disorder called porphyria.

  • If you are taking other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines. This is especially important if you have recently taken a medicine for depression, known as a monoamine-oxidase inhibitor (MAOI).

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nortriptyline and will provide you with a full list of the side-effects which you may experience from taking it.

  • It is usual to take three or four doses of nortriptyline a day, although it can also be prescribed as a single dose to be taken at bedtime. The directions for taking it will be printed on the label of the pack to remind you what the doctor said to you. If you have any questions about what dose to take, ask your pharmacist for advice.

  • Your doctor is likely to prescribe you a small dose when you first start taking it, and then increase your dose gradually as your body gets used to it.

  • Many people find if helps to swallow the tablets with a drink of water. You can take nortriptyline before or after meals.

  • If you forget to take a dose, take one as soon as you remember. If when you remember, it is nearly time for your next dose then leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

  • Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.

  • If you are taking nortriptyline for depression, you may feel that it is not working for you straightaway. It can take a week or two for the effect to build up, and 4-6 weeks before you feel the full benefit. It is important that you do not stop taking it thinking it is not helping. Also, while you feel depressed, you may have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway. There are several types of antidepressants - each type works in a slightly different way and can have different side-effects. If you find that nortriptyline does not suit you then let your doctor know, as another antidepressant may be found that does.

  • Your doctor will recommend that you do not drink alcohol while you are on nortriptyline. This is because it increases the risk of side-effects, such as feeling sleepy.

  • Some people who take nortriptyline find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.

  • Your doctor may ask you to carry on taking nortriptyline even after you feel better. This is to help stop your symptoms from returning.

  • If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because a number of medicines can increase the risk of side-effects from nortriptyline, including some strong painkillers, flu remedies and antihistamines which can be bought from pharmacies.

  • If you have diabetes you may need to check your blood glucose more frequently. This is because nortriptyline can alter the levels of sugar in your blood. Your doctor will advise you about this.

  • If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking nortriptyline as it can interfere with some anaesthetics.

  • Continue to take nortriptyline unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nortriptyline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common nortriptyline side-effects

Vad kan jag göra om jag upplever detta?

Torr mun

Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller

Förstoppning

Try to eat a well-balanced diet containing plenty of fibre and drink plenty of water each day

Feeling sleepy, blurred vision

Do not drive and do not use tools or machines until you feel better. Do not drink alcohol

Känner dig sjuk (illamående), diarré

Stick to simple meals - avoid rich or spicy foods. Drink plenty of water to replace lost fluids

Feeling dizzy or light-headed when getting up

Getting up more slowly may help. If you begin to feel faint, sit down and wait until the feeling passes

Other side-effects include feeling anxious or confused, sleeping problems, problems passing urine, tingling feelings, breast tenderness, problems when having sex, changes in appetite and weight, changes in the way things taste, ringing noise in the ears, itchy skin rash, hair loss, increased sweating, changes in heart rate or rhythm

If any of these become troublesome, speak with your doctor for advice

Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Never take more than the prescribed dose. Tricyclic antidepressants can be dangerous in overdose. If you suspect that you or someone else might have taken an overdose, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vanliga frågor

Can nortriptyline be used for conditions other than depression?

Yes, although nortriptyline is primarily licensed for depression, it is also commonly prescribed to help ease certain types of nerve pain. If you've been prescribed it for this reason, you should discuss any questions with your doctor.

How long does it take for nortriptyline to start working for depression?

You may not feel the effects of nortriptyline straight away for depression. It can take one to two weeks for the effect to build up, and typically four to six weeks before you experience the full benefit. It's important to continue taking it during this time.

What should I do if I forget to take a dose of nortriptyline?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, you should skip the missed dose and just take your next dose when it's due. Do not take a double dose to make up for the one you missed.

Why is alcohol not recommended while taking nortriptyline?

Your doctor will likely advise you not to drink alcohol while using nortriptyline because it can increase the risk of side-effects, such as feeling sleepy.

Can nortriptyline affect my blood sugar levels if I have diabetes?

Yes, nortriptyline can alter the levels of sugar in your blood. If you have diabetes, your doctor may ask you to check your blood glucose more frequently and will provide advice on this.

Is it safe to stop taking nortriptyline once I feel better?

No, your doctor may recommend you continue taking nortriptyline even after your symptoms improve to help prevent them from returning. Stopping treatment suddenly can cause problems, and your doctor may want to reduce your dose gradually when it's time to stop.

Are there any over-the-counter medicines I should be careful with while taking nortriptyline?

Yes, a number of medicines, including some strong painkillers, flu remedies, and antihistamines available from pharmacies, can increase the risk of side-effects from nortriptyline. Always check with a pharmacist to ensure any over-the-counter medicines are suitable for you.

Vidare läsning och referenser

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • Next review due: 18 Sept 2026
  • 19 Sept 2023 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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