Progesteron
Cyclogest, Utrogestan
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 9 Jan 2023
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Progesterone is a natural female sex hormone.
Follow carefully the directions your doctor gives to you about taking progesterone. It is prescribed for a selected number of days each month.
Any side-effects are usually mild, but may include feeling sick (nausea), weight gain, and headache.
At a glance
Progesterone is a female hormone used for various gynaecological problems, including fertility issues and irregular periods.
It is available as capsules, vaginal gel, vaginal capsules, pessaries, and injections.
You will be told by your doctor how and when to use your specific progesterone medicine.
Common side-effects can include feeling sick, headaches, and irregular periods.
If you have diabetes, you may need to check your blood sugar more often.
Let your doctor know your full medical history before starting progesterone.
Avoid smoking and excessive alcohol use while taking progesterone.
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About progesterone
Typ av medicin | A progestogen |
Används för | A variety of gynaecological problems, including infertility, in early pregnancy, and as part of hormone replacement therapy (HRT) |
Även kallad | Crinone® vaginal gel; Cyclogest® pessaries; Lubion® injection; Lutigest® vaginal tablets; Utrogestan® capsules and vaginal capsules |
Tillgänglig som | Capsules, vaginal gel, vaginal capsules, pessaries and injection |
Progesterone is a naturally occurring female sex hormone which is essential for the function of the female reproductive system. It is produced in the ovaries during the second half of the menstrual cycle, and also by the placenta during pregnancy. The amount of progesterone a woman produces declines during the menopause.
You will have been prescribed progesterone to supplement your naturally produced progesterone for a reason which your doctor will have explained to you. It works by adjusting the balance of your body's own hormones.
Progesterone is available in a number of formulations that are the subject of this leaflet (gel, injection, capsules, and pessaries). Each formulation is prescribed for a different gynaecological reason.
Progesterone may also be included as an ingredient in a number of combination products used for a variety of medical reasons. These products are not covered by this leaflet and you should read the printed information provided by your doctor and the manufacturer.
Before taking progesterone
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking progesterone, it is important that your doctor knows:
Om du är gravid eller ammar.
If you have migraines, asthma, epilepsy or high blood pressure.
If you are having any vaginal bleeding other than your normal monthly period.
If you have ever had a blood clot in your legs or lungs.
Om du har en hjärtsjukdom.
If you have had any problems with the way your liver or kidneys work.
If you have ever had depression.
If you have too much sugar in your blood (diabetes mellitus).
If you have cancer.
If during a pregnancy you had problems such as severe itching, yellowing of your skin or of the whites of your eyes (jaundice), or a skin condition called pemphigoid gestationis.
If you have a rare inherited blood disorder called porphyria.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
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How to take progesterone
Tillbaka till innehållBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the brand of progesterone you have been given. It will also provide a full list of side-effects which you may experience.
Follow carefully the instructions your doctor has given you. Progesterone is usually only used on a number of specified days during a monthly cycle. This may range from 4 to 25 days of a month depending on the reason it has been prescribed for you. If you are unsure about what to do, check again with your doctor.
If you have been prescribed:
Utrogestan® capsules as HRT: these should be taken at bedtime, on an empty stomach. This means that you should not take them with or soon after eating food. Just take them on the days of the month your doctor has told you to. You will also be prescribed an oestrogen-containing HRT medicine to take throughout the month.
Utrogestan vaginal® capsules for fertility treatment: use the applicator and follow the manufacturer's instructions for inserting the capsule high into the vagina. Do not take the capsule by mouth, although if you do swallow it accidentally, it will not harm you. The capsules are usually prescribed during the first three months of pregnancy only.
Lutigest® vaginal tablets for fertility treatment: put one tablet into the end of the applicator and use it to insert the tablet into the vagina following the manufacturer's instructions. Push the plunger to release the tablet. The usual dose is one tablet inserted three times daily starting on the day of egg retrieval. You will need to continue using Lutigest® for 30 days if pregnancy is confirmed. Follow the instructions of your doctor.
Crinone® vaginal gel for fertility treatment: use one 'applicatorful' daily into the vagina. Just use it on the days of the month your doctor has told you to.
Cyclogest® pessaries for menstrual problems: use twice daily on the days of the month your doctor has told you to. Pessaries are generally designed to be inserted into the vagina, but Cyclogest® pessaries are also suitable to be inserted into the back passage, as a suppository. If you are unsure which is the correct way for you to use them, check again with your doctor.
Lubion® injection for fertility treatment: make sure you know how to use this injection. If you are unsure which days to use it, or how much to use, check again with your doctor or clinic.
Få ut det mesta av din behandling
Tillbaka till innehållTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, remember to keep any routine appointments for breast screening and cervical smear tests.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are on progesterone.
If you have diabetes you may need to check your blood glucose more frequently, as progesterone can affect the levels of sugar in your blood. Your doctor will advise you about this.
It is best to avoid smoking and drinking too much alcohol while on progesterone. If you are a smoker and you would like advice on how to quit, speak with your doctor or pharmacist.
If you buy any medicines, check with a pharmacist that they are suitable to take with progesterone. This is because some herbal preparations (such as St John's wort) can interfere with the way it works.
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Can progesterone cause problems?
Tillbaka till innehållAlong with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with progesterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve over the first few days of taking or using a new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.
Common progesterone side-effects | Vad kan jag göra om jag upplever detta? |
Känner dig illamående (nausea) | Eat simple meals (avoid rich or spicy foods) |
Huvudvärk | Ask your pharmacist to recommend a suitable painkiller. If the headaches continue or are unusually severe, speak with your doctor as soon as possible |
Irregular periods, breast tenderness, weight changes, feeling dizzy or sleepy, difficulty sleeping, changes in sexual desire, mood changes, skin rash, acne-like spots, changes in hair growth, swollen feet and ankles (due to fluid retention) | Speak with your doctor if any of these become troublesome |
Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.
How to store progesterone
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

Osäker på att blanda mediciner?
Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What is the typical timeframe for using progesterone during a monthly cycle?
Progesterone is usually used for a specific number of days each month, which can vary from 4 to 25 days. The exact duration depends on the specific reason your doctor has prescribed it.
Are there any specific lifestyle recommendations while taking progesterone, such as diet or exercise?
While on progesterone, it is best to avoid smoking and drinking too much alcohol. If you have diabetes, you may need to check your blood glucose levels more often as progesterone can affect them. The article does not mention specific dietary or exercise recommendations beyond this.
What should I do if I forget to take a dose of my progesterone medicine?
The article does not specify what to do if you miss a dose. It is important to follow your doctor's instructions carefully for how to take progesterone, and if you are unsure about what to do, you should check with your doctor again.
Can progesterone affect my ability to drive or operate machinery?
Some of the common side-effects of progesterone include feeling dizzy or sleepy. If you experience these effects, it's best to speak with your doctor or pharmacist, and exercise caution when performing activities that require alertness.
How long will it take for the side-effects of progesterone to improve?
The unwanted side-effects often improve during the first few days of starting or using a new progesterone medicine. If any side-effects continue or become bothersome, you should speak with your doctor or pharmacist.
What should I do if I accidentally swallow a Utrogestan vaginal® capsule?
If you accidentally swallow a Utrogestan vaginal® capsule, it will not harm you. These capsules are designed for vaginal insertion for fertility treatment, but swallowing them accidentally is not dangerous.
Can I use Cyclogest® pessaries in different ways than just vaginally?
Yes, Cyclogest® pessaries are generally designed for vaginal insertion, but they are also suitable to be inserted into the back passage (rectum) as a suppository. If you are unsure which method is correct for you, you should check with your doctor.
Vidare läsning och referenser
- Manufacturer's PIL, Cyclogest® 200 mg Pessaries; L.D. Collins & Co. Ltd, The electronic Medicines Compendium. Dated March 2022.
- Manufacturer's PIL, Utrogestan® 100 mg Capsules; Besins Healthcare (UK) Ltd, The electronic Medicines Compendium. Dated February 2022.
- Manufacturer's PIL, Utrogestan Vaginal® 200 mg Capsules; Besins Healthcare (UK) Ltd, The electronic Medicines Compendium. Dated July 2022.
- Manufacturer's PIL, Crinone® 8% Progesterone Vaginal Gel; Merck Serono Ltd, The electronic Medicines Compendium. Dated December 2020.
- Manufacturer's PIL, Lutigest® vaginal tablets; Ferring Pharmaceuticals Ltd, The electronic Medicines Compendium. Dated October 2014.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 8 Jul 2027
9 Jan 2023 | Senaste versionen

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