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Selegilin för Parkinsons sjukdom

Eldepryl

Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 7 Aug 2023

Uppfyller patientens redaktionella riktlinjer

The usual dose is one tablet daily.

Keep your regular appointments with your doctor so your progress can be monitored.

As your symptoms improve and your body movements become easier, be careful not to overdo physical activities.

Do not stop taking this medicine without speaking with your doctor first - stopping suddenly can cause problems.

Överblick

  • Selegiline is a medicine used to treat Parkinson's disease.

  • It works by increasing the effect of dopamine in the brain, helping to ease symptoms like tremor and stiffness.

  • You can take one tablet a day, usually in the morning, with or without food.

  • Do not stop taking selegiline suddenly without discussing it with your doctor.

  • Common side-effects include feeling sick, headaches, and feeling light-headed.

  • Always check with your doctor or pharmacist before taking other medicines with selegiline.

Denna sammanfattning har automatiskt genererats från artikelns innehåll för att hjälpa läsarna att snabbt förstå huvudpunkterna.

About selegiline

Typ av medicin

A monoamine-oxidase-B inhibitor

Används för

Parkinsons sjukdom

Även kallad

Eldepryl®

Tillgänglig som

Tabletter

The symptoms of Parkinsons sjukdom - tremor, stiffness and slow movement - are due to there being less of a chemical called dopamine in your brain. Selegiline works by increasing the effect of dopamine in the brain, and this helps to ease these typical symptoms.

You may be prescribed selegiline as a treatment on its own, or alongside other medicines for Parkinson's disease which contain a medicine called levodopa. When it is prescribed with other medicines, selegiline helps to prevent some of the problems which can occur with these other treatments. These problems may be referred to as 'end-of-dose' fluctuations, or 'on-off' symptoms.

Before taking selegiline

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking selegiline it is important that your doctor or pharmacist knows:

  • Om du är gravid eller ammar.

  • If you have a stomach or duodenal ulcer.

  • If you have high blood pressure, an irregular heartbeat, or angina pain.

  • If you have had a mental health problem (in particular, psychosis).

  • If you have a problem with the way your liver works, or with the way your kidneys work.

  • Om du har en sällsynt ärftlig blodsjukdom som kallas porfyri.

  • Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

How to take selegiline

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about selegiline and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take selegiline exactly as your doctor tells you to. The usual dose is one tablet a day, in the morning. When you first start taking it your doctor is likely to suggest you start on the lower-strength (5 mg) tablet. You may then be prescribed the higher-strength (10 mg) tablet after a couple of weeks. You can take selegiline 5 mg and 10 mg tablets before or after food.

  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

Få ut det mesta av din behandling

  • Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.

  • As your condition improves and your body movements become easier, be careful not to overdo physical activities. You should increase your activity gradually to allow your body to adjust to any changes in balance, circulation and co-ordination.

  • If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on this medicine.

  • If you buy any medicines, check with a pharmacist that they are safe to take alongside this medicine. Selegiline should not be taken with strong painkillers and medicines containing sympathomimetics (present in some remedies for coughs and colds, and in decongestant nasal sprays and tablets).

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking selegiline.

  • Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary. Do not stop taking the medicine without speaking with your doctor first.

Can selegiline cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with selegiline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common

selegiline side-effects (these

affect more than 1 in 10 people)

Vad kan jag göra om jag upplever detta?

Sore mouth

Låt din läkare veta om detta

Common

selegiline side-effects

(these

affect fewer than 1 in 10 people)

Vad kan jag göra om jag upplever detta?

Feeling sick (nausea), stomach upset

Stick to simple foods - avoid rich or spicy meals. Drink plenty of water

Headache, other aches and pains

Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know

Feeling light-headed when getting up from a sitting or lying position

Getting up and moving more slowly should help. If this continues, speak with your doctor

Feeling tired, shaky or dizzy

Kör inte och använd inte verktyg eller maskiner förrän du mår bättre

Uncontrolled muscle movements

Låt din läkare veta om detta

Sleeping problems, feeling confused or depressed, hallucinations, blocked nose, sore throat, sweating

Om något av dessa blir besvärligt, tala med din läkare

Important: On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:

  • Stiff muscles or 'jerky' movements.

  • Unusually fast heartbeat.

  • High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.

  • Feeling delirious or seeing visions (hallucinating).

Om du upplever några andra symtom som du tror kan bero på medicinen, tala med din läkare eller apotekare för vidare råd.

How to store selegiline

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

symptomkontroll

Osäker på att blanda mediciner?

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Vanliga frågor

Can I take selegiline if I have an ulcer or heart condition?

It's important to inform your doctor or pharmacist if you have a stomach or duodenal ulcer, high blood pressure, an irregular heartbeat, or angina pain before starting selegiline. They will need to know about these conditions to ensure the medicine is suitable for you.

What should I do if I forget to take my selegiline tablet?

If you miss a dose, take it as soon as you remember. However, if you don't remember until the next day, you should skip the missed dose. Do not take two doses together to try and catch up for a forgotten dose.

Are there any specific activities I should be careful about when starting selegiline?

As your condition improves and your body movements become easier, be cautious not to overdo physical activities. It's recommended to increase your activity gradually to allow your body to adjust to any changes in balance, circulation, and coordination.

Can I take other medicines with selegiline, especially over-the-counter ones?

If you are buying any medicines, including those available without a prescription, or herbal remedies, always check with a pharmacist to make sure they are safe to take with selegiline. Selegiline should specifically not be taken with strong painkillers or medicines containing sympathomimetics, which are found in some cough and cold remedies, and decongestant nasal sprays and tablets.

What should I do if I need to stop taking selegiline?

Stopping this treatment suddenly can cause problems. If it becomes necessary to stop, your doctor will likely want you to reduce your dose gradually. Always speak with your doctor before you stop taking the medicine.

What are the common side effects of selegiline and what should I do about them?

Some common side effects include a sore mouth, feeling sick, stomach upset, headache, other aches and pains, feeling light-headed when standing up, feeling tired, shaky, or dizzy, and uncontrolled muscle movements. Many unwanted effects often improve as your body adjusts. For specific issues like feeling sick or headache, sticking to simple foods, drinking plenty of water, or asking your pharmacist for a suitable painkiller can help. If any side effects continue or become troublesome, or for more serious ones like uncontrolled muscle movements, feeling confused, sleeping problems, or hallucinations, you should speak with your doctor or pharmacist.

Dessa frågor och svar har genererats från informationen i denna artikel.

Vidare läsning och referenser

  • Manufacturer's PIL, Eldepryl® Tablets, Orion Pharma (UK) Limited, The electronic Medicines Compendium. Dated March 2021.
  • Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

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