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Mucositis

I denna serie:Mouth care

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Mucositis affects the lining of your mouth or gut (bowel) and is often caused by chemotherapy or radiotherapy.

Mucositis is often very painful and needs strong painkillers to help control the pain. It often interferes with eating and drinking and has a very negative effect on your quality of life. However, it can be prevented, can be treated and usually gets better soon after the treatment with chemotherapy or radiotherapy has stopped.

At a glance

  • Mucositis is soreness and inflammation in your mouth or gut.

  • It is a common side-effect of cancer treatments like chemotherapy and radiotherapy.

  • Symptoms include a sore mouth, difficulty eating, and sometimes diarrhoea.

  • Regular mouth care, painkillers, and diet changes can help manage symptoms.

  • Good dental hygiene and certain medicines may help prevent it.

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What is mucositis?

Mucositis occurs when your mouth or gut (bowel) becomes very sore and inflamed, often as a side-effect of chemotherapy or radiotherapy when used to treat cancer.

Mucositis affecting the mouth is common and occurs in about 1-2 people out of every 5 people receiving chemotherapy. The risk increases to 8 out of every 10 people receiving high-dose chemotherapy.

Nearly all people receiving head and neck radiotherapy will develop some degree of mucositis affecting the mouth. If you are treated with radiotherapy for your pelvis there is a high risk of developing mucositis affecting your gut (bowel).

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The symptoms of mucositis usually begin around 1 to 2 weeks after starting cancer treatment. The symptoms will depend on whether it is your mouth or your gut (bowel) that is affected.

The symptoms of mucositis affecting the mouth include:

  • Sore mouth. This can vary from just soreness and redness to severe pain and mouth ulceration.

  • Difficulty with eating and drinking.

  • Dry mouth and lips.

Diarrhoea, bleeding from your back passage (rectal bleeding), or pain when pooing may occur when mucositis affects your gut.

Mucositis should get better within a few weeks of finishing cancer treatment. However there are things you can do and treatments that can help to make it a lot better.

The most important way to treat mucositis affecting your mouth is by regular mouth care. Keeping your mouth clean and making changes to your diet can help if you have mucositis affecting your mouth. The simple measures you can do to treat mucositis affecting your mouth include:

  • Brush your teeth at least twice a day.

  • Use a soft toothbrush.

  • Use dental floss regularly.

  • Rinse your mouth with warm salt water several times a day.

  • Suck on crushed ice or ice lollies.

  • Eat soft, moist foods.

  • Drink plenty of water.

  • Only use a mouthwash that has been prescribed or recommended by your doctor or nurse. Mouthwashes can help to clean your mouth and reduce the discomfort, but some mouthwashes may irritate your mouth and make the symptoms worse.

  • Avoid eating crunchy, rough or sharp foods (like crisps).

  • Avoid eating hot, spicy or salty foods.

  • Avoid eating acidic foods, such as oranges or lemons.

  • Avoid drinking hot drinks, fizzy drinks or alcohol.

  • Don't smoke.

Your doctor or cancer care team will also be able to offer advice and provide treatments for mucositis, including:

For mucositis affecting your gut (bowel), medicines to stop diarrhoea or reduce soreness inside your back passage (anus) can help.

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All the advice outlined in the treatment section above can also be used to help reduce your risk of having mucositis. You don't have to wait until you do have a problem. Start this mouth care as soon as you know you are going to be treated with radiotherapy or chemotherapy.

Mucositis affecting your mouth is also more likely if you have dental problems such as caries or gum disease. So it's also very important to see a dentist and a dental hygienist to get any treatment and advice to treat or prevent any dental problems.

Using ice treatment (cryotherapy), such as putting ice chips in your mouth during chemotherapy, may also help to prevent as well as treat mucositis affecting your mouth.

If you are being treated for a cancer in your pelvis, probiotic agents containing lactobacillus can be used to help prevent chemotherapy- and radiation‐induced diarrhoea. Mucositis affecting your gut (bowel) can also be prevented by using certain medicines; your cancer specialist (oncologist) will give you advice about this. This will depend on exactly what treatment you are given.

Vanliga frågor

What is the approximate duration of mucositis after cancer treatment ends?

Mucositis should typically improve and get better within a few weeks after you have completed your cancer treatment when the chemotherapy or radiotherapy has finished.

Are there specific mouthwashes I should use or avoid if I have mucositis?

You should only use a mouthwash that has been prescribed or recommended by your doctor or nurse. Some mouthwashes can irritate your mouth and worsen symptoms, so it’s important to get advice on suitable options that can help clean your mouth and reduce discomfort.

Can I continue to consume my regular diet if I develop mucositis, or do I need to make changes?

If you have mucositis, you should make changes to your diet. It's best to eat soft, moist foods and drink plenty of water. You should avoid crunchy, rough, sharp, hot, spicy, salty, or acidic foods (like oranges or lemons), as well as hot drinks, fizzy drinks, and alcohol, as these can irritate your mouth.

Does mucositis from radiotherapy affect the same areas of the body as mucositis from chemotherapy?

Mucositis can affect different areas depending on the type and location of cancer treatment. Radiotherapy to the head and neck typically causes mucositis in the mouth, while radiotherapy to the pelvis carries a high risk of mucositis affecting the gut (bowel). Chemotherapy, on the other hand, is a more general treatment and can cause mucositis in both the mouth and gut, regardless of the cancer's location.

If I develop mucositis in my gut, are there any specific medications or interventions that can help?

Yes, if mucositis affects your gut (bowel), there are medicines that can help. These include medications to stop diarrhoea or to reduce soreness inside your back passage (anus). Your cancer specialist (oncologist) will be able to advise on what treatments are appropriate for your specific situation.

Is there anything I can do to prepare my mouth and reduce the risk of getting mucositis before starting cancer treatment?

Yes, you can take steps to reduce your risk of mouth mucositis before treatment starts. It's important to see a dentist and dental hygienist to address any dental problems like caries or gum disease. Additionally, you should begin regular mouth care as soon as you know you'll be having chemotherapy or radiotherapy, including brushing your teeth at least twice a day with a soft toothbrush, using dental floss, and rinsing with warm salt water several times daily.

Can I still smoke if I have mucositis?

No, you should avoid smoking if you have mucositis. Smoking can irritate your mouth and potentially worsen the symptoms, so it's advised to stop.

Vidare läsning och referenser

  • Riley P, Glenny AM, Worthington HV, et al; Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochrane Database Syst Rev. 2015 Dec 23;(12):CD011552. doi: 10.1002/14651858.CD011552.pub2.
  • Chaveli-Lopez B, Bagan-Sebastian JV; Treatment of oral mucositis due to chemotherapy. J Clin Exp Dent. 2016 Apr 1;8(2):e201-9. doi: 10.4317/jced.52917. eCollection 2016 Apr.
  • Lalla RV, Bowen J, Barasch A, et al; MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014 May 15;120(10):1453-61. doi: 10.1002/cncr.28592. Epub 2014 Feb 25.
  • Al-Ansari S, Zecha JA, Barasch A, et al; Oral Mucositis Induced By Anticancer Therapies. Curr Oral Health Rep. 2015;2(4):202-211. doi: 10.1007/s40496-015-0069-4. Epub 2015 Oct 19.
  • Campos MI, Campos CN, Aarestrup FM, et al; Oral mucositis in cancer treatment: Natural history, prevention and treatment. Mol Clin Oncol. 2014 May;2(3):337-340. doi: 10.3892/mco.2014.253. Epub 2014 Feb 7.

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About the authorView full bio

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Dr Colin Tidy, MRCGP

General Practitioner, Medical Author

MBBS, MRCGP, MRCP (Paediatrics), DCH

Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.

About the reviewerView full bio

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Dr Adrian Bonsall, MBBS

Medical Author

MA (Chemistry), MBBS (Hons), DCH

Since 2000 Adrian has been employed in emergency and critical care paediatrics based in Sydney, with particular interests in toxicology, trauma and resuscitation.

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