dual oxidase 2
Senast uppdaterad 18 aug 2020
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Den DUOX2 gene provides instructions for making an enzyme called dual oxidase 2. This enzyme is found in the thyroid gland, which is a butterfly-shaped tissue in the lower neck. The enzyme is also found in salivary glands, the digestive tract, and airways in the throat and lungs. Dual oxidase 2 helps generate a chemical called hydrogen peroxide. In the thyroid, hydrogen peroxide is required for one of the final steps in the production of thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
Normal function
Den DUOX2 gene provides instructions for making an enzyme called dual oxidase 2. This enzyme is found in the thyroid gland, which is a butterfly-shaped tissue in the lower neck. The enzyme is also found in salivary glands, the digestive tract, and airways in the throat and lungs. Dual oxidase 2 helps generate a chemical called hydrogen peroxide. In the thyroid, hydrogen peroxide is required for one of the final steps in the production of thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
Conditions referring to this gene or chromosome
Other names
DUOX2_HUMAN
flavoprotein NADPH oxidase
LNOX2
NADPH thyroid oxidase 2
nicotinamide adenine dinucleotide phosphate oxidase
NOXEF2
P138-TOX
THOX2
Related patient information and medicines
Patient information leaflet
Kan jag ta Metotrexat och Paracetamol tillsammans?
Dairy products Milk and dairy products contain an enzyme called xanthine oxidase which can break down methotrexate in the digestive tract. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer This information is for general educational.
Patient information leaflet
Kan jag ta Metotrexat och Ibuprofen tillsammans?
Dairy products Milk and other dairy products contain an enzyme called xanthine oxidase which can break down methotrexate before it is absorbed. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements a... Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
Läkemedel för urinträngningar och inkontinens
Medicines for urge incontinence Medicines from a different class to duloxetine, called antimuscarinics (also called anticholinergics), are used to help treat urge incontinence. Editor's note Dr Krishna Vakharia , 13th September 2024 Vibegron for treating symptoms of overactive bladder syndrome The National Institute for Health and Care Excellence.
Patient information leaflet
Kan jag ta Allopurinol och Mirtazapin tillsammans?
There are no known significant interactions between allopurinol and mirtazapine. It is generally considered safe to take these two medications together. Why this happens Allopurinol and mirtazapine are processed by different pathways in the body. Allopurinol works by blocking an enzyme called xanthine oxidase to lower uric acid levels, while.
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Kan jag ta Fenelzin och Tyramin tillsammans?
In extreme cases, this can lead to a stroke or heart attack. Why this happens Phenelzine is a Monoamine Oxidase Inhibitor (MAOI). It works by blocking an enzyme (MAO) that normally breaks down tyramine in your gut and liver. Always check with a pharm... Food and drink warnings Tyramine-rich foods (e.g., aged cheeses, cured meats, yeast extracts).
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Parkinsons sjukdom
(This could be linked to some types of medication - see 'Which medicines är used to treat Parkinson's disease?' section, below.). Also, for reasons that are unclear, people with a medical history of PD have... Which medicines are used to treat Parkinson's disease. Guidelines recommend starting with a dopamine agonist, levodopa with a.
Vidare läsning och referenser
- dual oxidase 2; MedlinePlus, National Library of Medicine.
- De Deken X, Wang D, Dumont JE, Miot F. Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. Exp Cell Res. 2002 Feb 15;273(2):187-96. doi: 10.1006/excr.2001.5444.
- El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, Morand S, Gnidehou S, Agnandji D, Ohayon R, Kaniewski J, Noel-Hudson MS, Bidart JM, Schlumberger M, Virion A, Dupuy C. Dual oxidase2 is expressed all along the digestive tract. Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G933-42. doi: 10.1152/ajpgi.00198.2004. Epub 2004 Dec 9.
- Forteza R, Salathe M, Miot F, Forteza R, Conner GE. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005 May;32(5):462-9. doi: 10.1165/rcmb.2004-0302OC. Epub 2005 Jan 27.
- Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003 Aug;17(11):1502-4. doi: 10.1096/fj.02-1104fje. Epub 2003 Jun 3.
- Jin HY, Heo SH, Kim YM, Kim GH, Choi JH, Lee BH, Yoo HW. High frequency of DUOX2 mutations in transient or permanent congenital hypothyroidism with eutopic thyroid glands. Horm Res Paediatr. 2014;82(4):252-60. doi: 10.1159/000362235. Epub 2014 Sep 20.
- Varela V, Rivolta CM, Esperante SA, Gruneiro-Papendieck L, Chiesa A, Targovnik HM. Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. Clin Chem. 2006 Feb;52(2):182-91. doi: 10.1373/clinchem.2005.058321. Epub 2005 Dec 1.
- Wang F, Lu K, Yang Z, Zhang S, Lu W, Zhang L, Liu S, Yan S. Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes. Clin Endocrinol (Oxf). 2014 Sep;81(3):452-7. doi: 10.1111/cen.12469. Epub 2014 May 19.
Artikelhistorik
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18 aug 2020 | Senaste versionen
1 Sept 2015 | Ursprungligen publicerad
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