intraflagellar transport 122
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Den IFT122 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells. Cilia participate in signaling pathways that transmit information within and between cells and are important for the development and function of many types of cells and tissues, including cells in the kidneys and liver and the light-sensitive tissue at the back of the eye (the retina). Cilia also play a role in the development of the bones, although the mechanism is not well understood.
Normal function
Den IFT122 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells. Cilia participate in signaling pathways that transmit information within and between cells and are important for the development and function of many types of cells and tissues, including cells in the kidneys and liver and the light-sensitive tissue at the back of the eye (the retina). Cilia also play a role in the development of the bones, although the mechanism is not well understood.
The movement of substances within cilia and similar structures called flagella is known as intraflagellar transport. This process is essential for the assembly and maintenance of these cell structures. During intraflagellar transport, cells use molecules called IFT particles to carry materials to and from the tips of cilia. Each IFT particle is made up of two groups of IFT proteins: complex A and complex B. The protein produced from the IFT122 gene forms part of IFT complex A (IFT-A). During intraflagellar transport, this complex carries materials from the tip to the base of cilia.
The IFT-A complex is essential for proper regulation of the Sonic Hedgehog signaling pathway, which is important for the growth and maturation (differentiation) of cells and the normal shaping (patterning) of many parts of the body, especially during embryonic development. The exact role of the complex in this pathway is unclear.
Conditions referring to this gene or chromosome
Other names
CED
CED1
IF122_HUMAN
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport protein 122 homolog
SPG
WD repeat domain 10
WD repeat-containing protein 10
WD repeat-containing protein 140
WDR10
WDR10p
WDR140
Related patient information and medicines
Patient information leaflet
Kan jag ta Mirabegron och Rivaroxaban tillsammans?
Taking these two medicines together... Why this happens Mirabegron and rivaroxaban are processed by different pathways in the body. Mirabegron is primarily broken down by enzymes called CYP3A4 and CYP2D6, while rivaroxaban is processed by CYP3A4 and a transport protein called P-gp. While they share the CYP3A4 pathway, studies show that mirabegron.
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Kan jag ta Alogliptin och Apixaban tillsammans?
There are no known significant interactions between alogliptin and apixaban. It is generally ... Why this happens Alogliptin (a diabetes medication) and apixaban (a blood thinner) are processed by different pathways in the body. Alogliptin is primarily excreted unchanged by the kidneys, while apixaban is processed by specific liver enzymes.
Patient information leaflet
Kan jag ta Atorvastatin och Rivaroxaban tillsammans?
Taking atorvastatin and rivaroxaban together may slightly increase the levels of rivaroxaban in your blood. Why this happens Both medications are processed by the same enzyme system in the liver (CYP3A4) and a transport protein (P-gp). Beca... Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Patient information leaflet
Kan jag ta Nortriptylin och Rosuvastatin tillsammans?
These two medicines work in different ways and are processed by different pathways in the body. Why this happens Nortriptyline is a tricyclic antidepressant primarily broken down by liver enzymes known as CYP2D6. Rosuvastatin is a statin used for cholesterol that is mostly processed by different enzymes (CYP2C9) and transport proteins. Because.
Patient information leaflet
Kan jag ta Apixaban och Empagliflozin tillsammans?
It is generally considered safe to take these two medications together. Why this happens Apixaban (a blood thinner) and empagliflozin (a diabetes medication) are processed by different pathways in the body. Apixaban is mainly broken down by specific liver enzymes (CYP3A4) and a transport protein (P-gp), while empagliflozin is processed through a.
Patient information leaflet
Kan jag ta Amlodipin och Apixaban tillsammans?
This could potentially increase the risk of bleeding or bruising, although for most people, this ef... Why this happens Both drugs är processed by the same enzyme in the liver (CYP3A4) and a transport protein (P-gp). Amlodipine can slightly slow down how quickly the body clears apixaban, leading to a minor increase in the amount of apixaban in.
Vidare läsning och referenser
- intraflagellar transport 122; MedlinePlus, National Library of Medicine.
- Liem KF Jr, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV. The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol. 2012 Jun 11;197(6):789-800. doi: 10.1083/jcb.201110049.
- Qin J, Lin Y, Norman RX, Ko HW, Eggenschwiler JT. Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1456-61. doi: 10.1073/pnas.1011410108. Epub 2011 Jan 5.
- Tan W, Lin A, Keppler-Noreuil K. Cranioectodermal Dysplasia. 2013 Sep 12 [updated 2022 Dec 15]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK154653/
- Walczak-Sztulpa J, Eggenschwiler J, Osborn D, Brown DA, Emma F, Klingenberg C, Hennekam RC, Torre G, Garshasbi M, Tzschach A, Szczepanska M, Krawczynski M, Zachwieja J, Zwolinska D, Beales PL, Ropers HH, Latos-Bielenska A, Kuss AW. Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene. Am J Hum Genet. 2010 Jun 11;86(6):949-56. doi: 10.1016/j.ajhg.2010.04.012. Epub 2010 May 20.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
18 aug 2020 | Senaste versionen
1 Nov 2013 | Ursprungligen publicerad
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