potassium voltage-gated channel subfamily E regulatory subunit 1
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Den KCNE1 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged potassium atoms (ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
Normal function
Den KCNE1 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged potassium atoms (ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. The KCNE1 protein regulates a channel made up of four parts, called alpha subunits, which are produced from the KCNQ1 gene. One beta subunit, produced from the KCNE1 gene, binds to the channel and regulates its activity.
These channels are active in the inner ear and in heart (cardiac) muscle, where they transport potassium ions out of cells. In the inner ear, the channels play a role in maintaining the proper ion balance needed for normal hearing. In the heart, the channels are involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm. The KCNE1 protein is also produced in the kidneys, testes, and uterus, where it probably regulates the activity of other channels.
Conditions referring to this gene or chromosome
Other names
delayed rectifier potassium channel subunit IsK
IKs producing slow voltage-gated potassium channel beta subunit Mink
ISK
JLNS2
KCNE1_HUMAN
LQT5
minimal potassium channel
minK
potassium channel, voltage gated subfamily E regulatory beta subunit 1
potassium voltage-gated channel, Isk-related family, member 1
Related patient information and medicines
Patient information leaflet
Kan jag ta Atenolol och Ramipril tillsammans?
Taking these two medicines together can cause your blood pressure to drop lower than intended, especially when you first start the combination or when your dose is increased. This might make you feel dizzy, lightheaded, or faint, particularly when standing up quickly. There is also a small risk that the combination could affect your kidney.
Patient information leaflet
Kan jag ta Co-amoxiclav och Ramipril tillsammans?
Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection. Why this happens Both drugs can.
Patient information leaflet
Can I take Bisoprolol and Ramipril together?
It can also occasionally lead to increased levels of po... Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that relaxes blood vessels. Because they both target the cardiovascular system, their effects add together (an.
Patient information leaflet
Kan jag ta Doxadura och Losartan tillsammans?
Combining them can make you feel very dizzy, lightheaded, or fain... It also increases the risk of falls. Potassium-rich foods and Salt Substitutes Losartan can increase the levels av kalium in your blood. You should avoid using salt substitutes (such as Lo-Salt) that contain potassium. You should also avoid consuming excessive amounts of.
Patient information leaflet
Kan jag ta Bisoprolol och Losartan tillsammans?
Tar bisoprolol and losartan together kan orsaken your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. It can also lead to increased levels of potassium in your blood. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol.
Patient information leaflet
Kan jag ta Nustendi och Ramipril tillsammans?
Tar Nustendi och ramipril together can increase the risk av your kidneys not working as well as they should. It may also lead to high levels of potassium in your blood (hyperkalaemia). Why this happens Nustendi contains two medicines: bempedoic acid and ezetimibe. Bempedoic acid can sometimes increase levels of uric acid and affect kidney.
Vidare läsning och referenser
- potassium voltage-gated channel subfamily E regulatory subunit 1; MedlinePlus, National Library of Medicine.
- Abbott GW. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene. 2016 Jan 15;576(1 Pt 1):1-13. doi: 10.1016/j.gene.2015.09.059. Epub 2015 Sep 26.
- Chan PJ, Osteen JD, Xiong D, Bohnen MS, Doshi D, Sampson KJ, Marx SO, Karlin A, Kass RS. Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1. J Gen Physiol. 2012 Feb;139(2):135-44. doi: 10.1085/jgp.201110672. Epub 2012 Jan 16.
- Ehmke H. Physiological functions of the regulatory potassium channel subunit KCNE1. Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R637-8. doi: 10.1152/ajpregu.00723.2001. No abstract available.
- Faridi R, Przybylski R, Saenen J, Hertzano R, Newman WG, Friedman TB. Jervell and Lange-Nielsen Syndrome. 2002 Jul 29 [updated 2026 Oct 15]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1405/
- Groffen AJ, Bikker H, Christiaans I. Long QT Syndrome Overview. 2003 Feb 20 [updated 2024 Mar 21]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1129/
- Lundquist AL, Turner CL, Ballester LY, George AL Jr. Expression and transcriptional control of human KCNE genes. Genomics. 2006 Jan;87(1):119-28. doi: 10.1016/j.ygeno.2005.09.004. Epub 2005 Nov 21.
- Melman YF, Um SY, Krumerman A, Kagan A, McDonald TV. KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron. 2004 Jun 24;42(6):927-37. doi: 10.1016/j.neuron.2004.06.001.
- Paulussen AD, Gilissen RA, Armstrong M, Doevendans PA, Verhasselt P, Smeets HJ, Schulze-Bahr E, Haverkamp W, Breithardt G, Cohen N, Aerssens J. Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. J Mol Med (Berl). 2004 Mar;82(3):182-8. doi: 10.1007/s00109-003-0522-z. Epub 2004 Feb 4.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
18 aug 2020 | Senaste versionen
1 Apr 2006 | Ursprungligen publicerad
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