Can I take Aspirin and Furosemide together?

Why this happens

Both drugs compete to be cleared out of the body by the kidneys. Aspirin can block the kidneys from responding to furosemide, meaning you don't pass as much urine. Furthermore, because they use the same 'exit route' in the kidneys, taking them together can slow down how quickly aspirin leaves your system.

What you should do

If you are taking low-dose aspirin (75mg to 150mg) for heart protection, the interaction is usually small, but you should still have your kidney function and blood pressure monitored by your GP. Avoid taking high-dose aspirin (for pain or fever) while on furosemide. If you notice increased swelling in your ankles, shortness of breath, or ringing in your ears, contact your doctor.

Important precautions

Asthma

Do not take aspirin if you have a history of asthma, as it can trigger a severe or life-threatening asthma attack.

Children under 16 years old

Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor, due to the risk of Reye’s syndrome, a rare but fatal condition.

Dehydration and electrolyte imbalance

Furosemide can cause severe dehydration and low potassium. You must report any signs of extreme thirst, muscle cramps, or dizziness to your doctor immediately.

Food and drink warnings

Alcohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

Liquorice (Natural) / Liquorice Root

Eating large amounts of natural liquorice can cause your body to lose potassium and retain salt and water. This can counteract the effects of furosemide and lead to dangerously low potassium levels.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.