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Can I take Hydroxychloroquine and Sildenafil together?

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Taking hydroxychloroquine and sildenafil together may increase the risk of developing an irregular heartbeat (heart arrhythmia). Both medications can affect the electrical activity of your heart, specifically a measurement called the 'QT interval'. If this interval becomes too long, it can lead to serious heart rhythm problems.

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Varför detta händer

Both hydroxychloroquine and sildenafil have the potential to affect the electrical activity of the heart, specifically by prolonging the 'QT interval' (the time it takes for the heart muscle to recharge between beats). When used together, this effect can be additive, potentially leading to a rare but serious heart rhythm disturbance.

You should speak to your doctor before using these medicines together, especially if you have a history of heart disease, heart rhythm problems, or electrolyte imbalances (such as low potassium or magnesium). Seek immediate medical help if you experience sudden dizziness, lightheadedness, fainting, or a racing/pounding heart.

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Eye health and vision

Hydroxychloroquine can cause permanent damage to the retina. You must have a baseline eye test before starting and regular annual screenings if you take it long-term. Report any new blurred vision or blind spots immediately.

Heart rhythm disorders

Hydroxychloroquine can affect your heart rhythm, especially if taken with other medicines that affect the heart. Seek immediate medical help if you experience palpitations, fainting, or severe dizziness.

Nitrate medication use

Never take sildenafil if you are using nitrates (such as glyceryl trinitrate or isosorbide mononitrate) for chest pain. Combining them can cause a sudden, life-threatening drop in blood pressure.

Priapism - sildenafil

If you experience an erection that lasts longer than 4 hours, seek immediate emergency medical attention to prevent permanent tissue damage.

Grapefruit juice

Grapefruit juice can increase the amount of sildenafil in your bloodstream. This may increase the risk of side effects such as headaches, flushing, or low blood pressure. It is best to avoid drinking large amounts of grapefruit juice while using this medication.

Alkohol

It is best to avoid or strictly limit alcohol while taking these medicines. For sildenafil, alcohol can make it harder to get an erection and may increase the risk of dizzy spells or low blood pressure. For hydroxychloroquine, both the medicine and alcohol are processed by the liver; combining them may increase the strain on your liver.

Fettrika måltider

Taking sildenafil with a heavy or high-fat meal (such as a burger and chips) can delay the medicine from working. It may take longer than usual for you to feel the effects. For the fastest results, take it on an empty stomach or with a light meal.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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