Can I take Ibuprofen and Oxycodone together?
Guide för läkemedelsinteraktioner
Ursprungligen publicerad 25 jan 2026
Uppfyller patientens redaktionella riktlinjer
- Ladda nerLadda ner
- Dela
- Language
- Diskussion
- Ljudversion
- Add to preferred sources on Google
Taking ibuprofen and oxycodone together can increase the risk of side effects affecting your stomach and kidneys. However, these two medicines are very commonly prescribed together because they work in different ways to provide better pain relief than either drug alone. The most common side effects include stomach ache, indigestion, or feeling dizzy and sleepy.
I den här artikeln:
Video picks for Läkemedelsinteraktioner
Fortsätt läsa nedan
Varför detta händer
Ibuprofen is an anti-inflammatory (NSAID) that can irritate the stomach lining and affect kidney blood flow. Oxycodone is an opioid that slows down the central nervous system. While they do not 'interfere' with how the body breaks each other down, their side effects can add up, particularly the risk of stomach upset and drowsiness.
Vad du bör göra
Tillbaka till innehållIt is generally safe to take these together if prescribed by your doctor, but you should take them with food to protect your stomach. Do not exceed the recommended dose of either medicine. Avoid drinking alcohol while taking this combination, as it will significantly increase drowsiness and the risk of breathing problems. If you have a history of stomach ulcers, kidney disease, or asthma, speak to your doctor before combining them.
Fortsätt läsa nedan
Viktiga försiktighetsåtgärder
Tillbaka till innehållRespiratory conditions (e.g. Asthma, COPD)
Oxycodone can cause life-threatening breathing difficulties. Do not take this medicine if you have severe asthma or serious lung problems.
Do not take ibuprofen if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Opioid dependence and withdrawal
Oxycodone is highly addictive. Long-term use leads to physical dependence; stopping suddenly can cause severe withdrawal symptoms. Use only for the shortest time possible.
Stomach ulcers or bleeding
Avoid ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding, as it can cause serious damage to the stomach lining.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.
Varningar för mat och dryck
Tillbaka till innehållAlkohol
It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.
It is best to avoid or strictly limit alcohol when taking oxycodone. Combining alcohol with this medicine significantly increases the risk of dangerous side effects, such as severe drowsiness, breathing difficulties, and a potentially fatal overdose.
Grapefruit juice
Avoid drinking grapefruit juice or eating grapefruit while taking oxycodone. Grapefruit can interfere with how your body breaks down the medicine, leading to higher levels of oxycodone in your blood, which increases the risk of serious side effects.
Food (General)
It is recommended to take ibuprofen with food or a glass of milk to reduce the risk of stomach upset or indigestion.
Fortsätt läsa nedan
Användning av andra läkemedel
Tillbaka till innehållTaking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Ansvarsfriskrivning
Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.
Patient picks for Läkemedelsinteraktioner

Läkemedelsinteraktionskontroll
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.

Läkemedelsinteraktionskontroll
Can I take Amlodipine and Ramipril together?
Taking these two medicines together can cause your blood pressure to drop lower than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. It can also increase the risk of your kidneys not working as well as they should or cause a rise in potassium levels in your blood.
Fortsätt läsa nedan
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
25 jan 2026 | Ursprungligen publicerad

Fråga, dela, anslut.
Bläddra i diskussioner, ställ frågor och dela erfarenheter inom hundratals hälsorelaterade ämnen.

Känner du dig sjuk?
Bedöm dina symtom online gratis
Anmäl dig till Patientens nyhetsbrev
Din veckovisa dos av tydliga, pålitliga hälsoråd - skrivna för att hjälpa dig känna dig informerad, självsäker och i kontroll.
By subscribing you accept our Sekretesspolicy. Du kan avsluta prenumerationen när som helst. Vi säljer aldrig dina uppgifter.