Can I take Losartan and Pregabalin together?

Why this happens

This is a 'pharmacodynamic' interaction, meaning the drugs have different ways of working but produce similar side effects. Losartan lowers blood pressure, while pregabalin can cause dizziness and sedation as it affects the nervous system. When combined, these effects can add up. Additionally, both drugs are occasionally linked to peripheral oedema (fluid swelling).

What you should do

It is generally safe to take these together, but you should be cautious, especially when starting the combination or increasing the dose. Avoid driving or operating machinery until you know how the mix affects you. To prevent dizziness, try to stand up slowly from a sitting or lying position. If you notice significant swelling in your ankles or feel unusually faint, contact your doctor.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Drug dependence and misuse

Pregabalin can lead to dependence and addiction. Do not increase your dose without medical advice, and do not stop taking it suddenly, as this can cause severe withdrawal symptoms.

Pregnancy

You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.

Pregabalin use during the first three months of pregnancy may increase the risk of birth defects. Effective contraception must be used during treatment.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with losartan can cause your blood pressure to drop too low, making you feel dizzy or faint. Combining alcohol with pregabalin can significantly increase drowsiness, dizziness, and breathing difficulties.

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.