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Kan jag ta Naproxen och Oxycodone tillsammans?

Guide för läkemedelsinteraktioner

Taking naproxen and oxycodone together can increase the risk of side effects, particularly affecting your stomach and kidneys. While they are often prescribed together for severe pain, the combination can increase the chance of stomach irritation, indigestion, or in more serious cases, stomach ulcers and bleeding. Additionally, both medications can put extra strain on your kidneys, especially if you are dehydrated or have existing kidney issues.

Varför detta händer

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that reduces protective chemicals in the stomach lining and affects blood flow to the kidneys. Oxycodone is an opioid painkiller. While they work in different ways to stop pain (additive effect), taking them together does not change how the body breaks them down, but it does increase the overall burden on your internal organs, particularly the digestive system and kidneys.

Vad du bör göra

You can take these medicines together if your doctor has specifically prescribed both, but you must use caution. Always take naproxen with food or a glass of milk to protect your stomach. Drink plenty of water to help your kidneys. If you notice any signs of stomach bleeding (such as black, tarry stools or coffee-ground-like vomit) or severe indigestion, stop taking the naproxen and contact your doctor immediately. Do not take more than the recommended dose of either medication.

Viktiga försiktighetsåtgärder

Opioid addiction and respiratory depression

Oxycodone is highly addictive and can lead to dependence. Taking too much, or mixing it with alcohol or benzodiazepines, can cause dangerously slow or shallow breathing which can be fatal.

Astma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Magsår eller blödning

Naproxen can cause serious stomach ulcers and internal bleeding. This risk is higher if you have had ulcers before, are over 65, or take other blood-thinning medicines. Stop taking it and see a doctor immediately if you have black, tarry stools or vomit blood.

Graviditet (tredje trimestern)

Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Varningar för mat och dryck

Alkohol

It is best to avoid or strictly limit alcohol when taking oxycodone. Combining alcohol with this medicine significantly increases the risk of dangerous side effects, such as severe drowsiness, breathing difficulties, and a potentially fatal overdose.

It is best to avoid or strictly limit alcohol while taking naproxen. Both alcohol and naproxen can irritate the lining of your stomach; combining them significantly increases your risk of developing stomach ulcers or internal bleeding.

Grapefruktjuice

Avoid drinking grapefruit juice or eating grapefruit while taking oxycodone. Grapefruit can interfere with how your body breaks down the medicine, leading to higher levels of the drug in your blood and increasing the risk of serious side effects.

Mat (Allmänt)

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Användning av andra läkemedel

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Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

Patientval för Läkemedelsinteraktioner

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
  • 25 jan 2026 | Ursprungligen publicerad

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Ansvarsfriskrivning: The views expressed in the community do not represent medical advice. For any health concerns, consult your GP or healthcare provider.

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