Complement factor I deficiency
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Complement factor I deficiency is a disorder that affects the immune system. People with this condition are prone to recurrent infections, including infections of the upper respiratory tract, ears, skin, and urinary tract. They may also contract more serious infections such as pneumonia, meningitis, and sepsis, which may be life-threatening.
Beskrivning
Complement factor I deficiency is a disorder that affects the immune system. People with this condition are prone to recurrent infections, including infections of the upper respiratory tract, ears, skin, and urinary tract. They may also contract more serious infections such as pneumonia, meningitis, and sepsis, which may be life-threatening.
Some people with complement factor I deficiency have a kidney disorder called glomerulonephritis with isolated C3 deposits. Complement factor I deficiency can also be associated with autoimmune disorders such as rheumatoid arthritis or systemic lupus erythematosus (SLE). Autoimmune disorders occur when the immune system malfunctions and attacks the body's tissues and organs.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal recessive. More than one pattern can apply in different cases.
Related genes
Other names
C3 inactivator deficiency
Complement component 3 inactivator deficiency
Hereditary factor I deficiency disease
Related patient information and medicines
Patient information leaflet
Brist på vitamin C
Vitamin C cannot be made by the human body and so is an essential component of the diet. It is needed for the health and repair of various tissues in the body, including skin, bone, teeth and cartilage. Persistent lack of dietary vitamin C in can lead to a condition called scurvy. Symptoms of scurvy include easy bruising, easy bleeding and joint.
Patient information leaflet
Vitamin D-brist
Vitamin D deficiency happens when your body does not have enough vitamin D. This is a nutrient that helps keep bones, teeth, and muscles healthy. Vitamin D deficiency is common, especially in people who get little sunlight or have low vitamin D intake from their diet. What is vitamin D deficiency. Vitamin D deficiency means you don’t have enough.
Patient information leaflet
Kan jag ta Vitamin B12 och Vitamin C tillsammans?
Why this happens ... G6PD-brist Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer.
Patient information leaflet
Kan jag ta magnesium och vitamin D tillsammans?
Magnesium is a necessary 'co-factor' for the enzymes that convert Vitamin D into its active form in the blood. Without enough magnesium, Vitamin D may remain ... Alcohol acts as a diuretic, which can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective. Additionally, chronic alcohol use.
Patient information leaflet
Hemofili
Hemofili is a rare bleeding disorder that affects your ability to make a clot. The blood contains substances called clotting factors that work with platelets to form a clot. Hemofili is a condition where there is a deficiency of clotting factors, so people with this condition usually have prolonged bleeding. Haemophilia is a rare bleeding.
Patient information leaflet
Kan jag ta Hydroxokobalamin och Lipitor tillsammans?
There are no known interactions between hydroxocobalamin (Vitamin B12) and Lipitor (atorvastatin). It is safe to take these two medications together. Why this happens These medications are processed by different pathways in the body. Hydroxocobalamin is a synthetic form of Vitamin B12 used to treat deficiencies, while Lipitor is a statin used to.
Vidare läsning och referenser
- Complement factor I deficiency; MedlinePlus, National Library of Medicine.
- Baracho GV, Nudelman V, Isaac L. Molecular characterization of homozygous hereditary factor I deficiency. Clin Exp Immunol. 2003 Feb;131(2):280-6. doi: 10.1046/j.1365-2249.2003.02077.x.
- Grumach AS, Leitao MF, Arruk VG, Kirschfink M, Condino-Neto A. Recurrent infections in partial complement factor I deficiency: evaluation of three generations of a Brazilian family. Clin Exp Immunol. 2006 Feb;143(2):297-304. doi: 10.1111/j.1365-2249.2005.02988.x.
- Nilsson SC, Trouw LA, Renault N, Miteva MA, Genel F, Zelazko M, Marquart H, Muller K, Sjoholm AG, Truedsson L, Villoutreix BO, Blom AM. Genetic, molecular and functional analyses of complement factor I deficiency. Eur J Immunol. 2009 Jan;39(1):310-23. doi: 10.1002/eji.200838702.
- Pettigrew HD, Teuber SS, Gershwin ME. Clinical significance of complement deficiencies. Ann N Y Acad Sci. 2009 Sep;1173:108-23. doi: 10.1111/j.1749-6632.2009.04633.x.
- Ponce-Castro IM, Gonzalez-Rubio C, Delgado-Cervino EM, Abarrategui-Garrido C, Fontan G, Sanchez-Corral P, Lopez-Trascasa M. Molecular characterization of Complement Factor I deficiency in two Spanish families. Mol Immunol. 2008 May;45(10):2764-71. doi: 10.1016/j.molimm.2008.02.008. Epub 2008 Mar 28.
- Vyse TJ, Morley BJ, Bartok I, Theodoridis EL, Davies KA, Webster AD, Walport MJ. The molecular basis of hereditary complement factor I deficiency. J Clin Invest. 1996 Feb 15;97(4):925-33. doi: 10.1172/JCI118515.
- Vyse TJ, Spath PJ, Davies KA, Morley BJ, Philippe P, Athanassiou P, Giles CM, Walport MJ. Hereditary complement factor I deficiency. QJM. 1994 Jul;87(7):385-401.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
18 aug 2020 | Senaste versionen
1 Sept 2010 | Ursprungligen publicerad
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