calcium sensing receptor
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The CASR gene provides instructions for making a protein called the calcium-sensing receptor (CaSR). Calcium molecules bind to CaSR, which allows this protein to monitor and regulate the amount of calcium in the blood.
Normal function
The CASR gene provides instructions for making a protein called the calcium-sensing receptor (CaSR). Calcium molecules bind to CaSR, which allows this protein to monitor and regulate the amount of calcium in the blood.
The CaSR protein is found in cells of the parathyroid glands. The four parathyroid glands are located in the neck. These glands produce and release a hormone called parathyroid hormone, which regulates the levels of calcium in the blood. When blood calcium levels are high, calcium binds to CaSR in the parathyroid glands and blocks the production of parathyroid hormone. Without parathyroid hormone, calcium is not released into the blood. CaSR signaling also blocks the growth and division (proliferation) of the cells that make up the parathyroid glands.
The CaSR protein is also found in kidney cells. Kidneys filter fluid and waste products in the body and can reabsorb needed nutrients and release them back into the blood. When calcium binds to CaSR in kidney cells, it blocks the reabsorption of calcium and allows it to be released in the urine.
Conditions referring to this gene or chromosome
Other names
calcium-sensing receptor
CAR
extracellular calcium-sensing receptor
GPRC2A
parathyroid Ca(2+)-sensing receptor 1
parathyroid cell calcium-sensing receptor
PCAR1
Related patient information and medicines
Patient information leaflet
Kan jag ta Kolekalciferol och Levotyroxin tillsammans?
Taking colecalciferol (Vitamin D3) and levothyroxine together is generally safe, but there is a small possibility that high doses of Vitamin D could affect how your thyroid medication works. Specifically, if Vitamin D significantly raises your calcium levels, it might change how your body responds to levothyroxine. However, Vitamin D helps the.
Patient information leaflet
Sköldkörtel- och bisköldkörtelproblem
This leaflet gives a brief overview of the thyroid and parathyroid glands och the common medical problems which can occur with these. What are the thyroid and parathyroid glands. Both the thyroid and parathyroid glands are endocrine glands. This means they make and release (secrete) hormones. Hormones are chemicals which are produced by the body.
Patient information leaflet
Betablockerare
Beta-blockers are medicines that are used to treat a variety of conditions. Their full correct name is beta-adrenoceptor blocking medicines (or beta-adrenergic blocking agents), but they are commonly just called beta-blockers. A common arrhythmi... Beta-blockers are often used to control the fast heart rate in atrial fibrillation. Calcium-channel.
Patient information leaflet
Kan jag ta Adcal-D3 och Kollagen tillsammans?
Det finns no known harmful interaction between Adcal-D3 and collagen supplements. Varför detta händer Adcal-D3 provides calcium and vitamin D3, while collagen provides amino acids. High blood calcium (Hypercalcaemia) You must not take Adcal-D3 if you have been told you have high levels of kalcium in your blood or urine (often caused by overactive.
Patient information leaflet
Hypoparatyreoidism
Hypoparatyreoidism occurs when too little parathyroid hormone is released by the parathyroid glands. Hypoparathyroidism leads to low levels of calcium in the blood, which can cause a number of different... Hypoparathyroidism can be successfully treated with calcium and vitamin D supplements but regular blood test monitoring is needed. The.
Patient information leaflet
Medicin mot högt blodtryck
For detailed information about your own medication you should read the leaflet that comes inside the medicine packet. What are the types of blood pressure medicines. There are six main classes of medicine... They have a similar effect to ACE inhibitors (described above) and blood tests are needed at the same times as with ACE inhibitors..
Vidare läsning och referenser
- calcium sensing receptor; MedlinePlus, National Library of Medicine.
- Cetani F, Pardi E, Aretini P, Saponaro F, Borsari S, Mazoni L, Apicella M, Civita P, La Ferla M, Caligo MA, Lessi F, Mazzanti CM, Torregossa L, Oppo A, Marcocci C. Whole exome sequencing in familial isolated primary hyperparathyroidism. J Endocrinol Invest. 2020 Feb;43(2):231-245. doi: 10.1007/s40618-019-01107-5. Epub 2019 Sep 5.
- Charoenngam N, Wattanachayakul P, Mannstadt M. CASRdb: A Publicly Accessible Comprehensive Database for Disease-Associated Calcium-Sensing Receptor Variants. J Clin Endocrinol Metab. 2025 Jan 21;110(2):297-302. doi: 10.1210/clinem/dgae769.
- English KA, Lines KE, Thakker RV. Genetics of hereditary forms of primary hyperparathyroidism. Hormones (Athens). 2024 Mar;23(1):3-14. doi: 10.1007/s42000-023-00508-9. Epub 2023 Dec 1.
- Hannan FM, Nesbit MA, Christie PT, Lissens W, Van der Schueren B, Bex M, Bouillon R, Thakker RV. A homozygous inactivating calcium-sensing receptor mutation, Pro339Thr, is associated with isolated primary hyperparathyroidism: correlation between location of mutations and severity of hypercalcaemia. Clin Endocrinol (Oxf). 2010 Dec;73(6):715-22. doi: 10.1111/j.1365-2265.2010.03870.x.
- Hendy GN, Guarnieri V, Canaff L. Calcium-sensing receptor and associated diseases. Prog Mol Biol Transl Sci. 2009;89:31-95. doi: 10.1016/S1877-1173(09)89003-0. Epub 2009 Oct 7.
- Kinoshita Y, Hori M, Taguchi M, Watanabe S, Fukumoto S. Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2014 Feb;99(2):E363-8. doi: 10.1210/jc.2013-3430. Epub 2013 Dec 2.
- Ranieri M, Tamma G, Di Mise A, Vezzoli G, Soldati L, Svelto M, Valenti G. Excessive signal transduction of gain-of-function variants of the calcium-sensing receptor (CaSR) are associated with increased ER to cytosol calcium gradient. PLoS One. 2013 Nov 14;8(11):e79113. doi: 10.1371/journal.pone.0079113. eCollection 2013.
- Raue F, Pichl J, Dorr HG, Schnabel D, Heidemann P, Hammersen G, Jaursch-Hancke C, Santen R, Schofl C, Wabitsch M, Haag C, Schulze E, Frank-Raue K. Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey. Clin Endocrinol (Oxf). 2011 Dec;75(6):760-5. doi: 10.1111/j.1365-2265.2011.04142.x.
- Thim SB, Birkebaek NH, Nissen PH, Host C. Activating calcium-sensing receptor gene variants in children: a case study of infant hypocalcaemia and literature review. Acta Paediatr. 2014 Nov;103(11):1117-25. doi: 10.1111/apa.12743. Epub 2014 Aug 24.
- Warner J, Epstein M, Sweet A, Singh D, Burgess J, Stranks S, Hill P, Perry-Keene D, Learoyd D, Robinson B, Birdsey P, Mackenzie E, Teh BT, Prins JB, Cardinal J. Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications. J Med Genet. 2004 Mar;41(3):155-60. doi: 10.1136/jmg.2003.016725.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
23 Jan 2026 | Senaste versionen
1 Jan 2026 | Ursprungligen publicerad
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