cation channel sperm associated 2
Senast uppdaterad 26 Apr 2024
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The CATSPER2 gene provides instructions for producing a protein that is found in the tail (flagellum) of sperm cells. The CATSPER2 protein plays a role in sperm cell movement (motility). It is one of four proteins that together form a hole (pore) that allows for the movement of charged calcium atoms (Ca2+) across the sperm cell membrane. Ca2+ is needed for a type of sperm motility called hyperactivation. Hyperactivation is characterised by vigorous movements of the sperm tail, allow the sperm to push through the membrane of the egg cell during fertilization.
Normal function
The CATSPER2 gene provides instructions for producing a protein that is found in the tail (flagellum) of sperm cells. The CATSPER2 protein plays a role in sperm cell movement (motility). It is one of four proteins that together form a hole (pore) that allows for the movement of charged calcium atoms (Ca2+) across the sperm cell membrane. Ca2+ is needed for a type of sperm motility called hyperactivation. Hyperactivation is characterised by vigorous movements of the sperm tail, allow the sperm to push through the membrane of the egg cell during fertilization.
Conditions referring to this gene or chromosome
Other names
cation channel, sperm associated 2
CTSR2_HUMAN
Related patient information and medicines
Patient information leaflet
Spermatest
A sperm test (semen analysis) is usually advised if a couple is having difficulty becoming pregnant (conceiving). The aim is to see if the semen and sperm made by the male partner are normal or not. What is a sperm test. A sperm test is also called a semen analysis. This is when a sample of ejaculate (semen) is examined under a microscope, to look.
Patient information leaflet
Aminosalicylater
Aminosalicylater are a group of medicines used to treat inflammation of the gut that are used to treat and prevent flare-ups av ulcerative colitis. What are aminosalicylates. Aminosalicylates are a group of medicines that can help to control the symptoms of some inflam... This may make you feel itchy, become more sensitive to sunlight or cause.
Patient information leaflet
Cri du chat-syndrom
Cri du chat syndrome is a chromosome problem caused by a missing piece of chromosome 5. The syndrome is called cri du chat (French for cry of the cat) because affected babies often have a high-pitched cry. Not all babies with the missing piece of chromosome 5 will develop cri du chat syndrome. Cri du chat syndrome may cause a variety of.
Patient information leaflet
Infertilitet
In some it only happens from time to time: some months ovulation occurs and some months it doesn't. There are various causes of ovulation problems including: Menopause. Premature ovarian insufficiency. In some couples, a condition which might affect fertility is found in the male partner. The most common reason for male infertilitet är ett problem.
Patient information leaflet
Mola graviditet
It needs to be removed and most women can expect a full recovery. What is a molar pregnancy. A molar pregnancy is a growing mass of tissue inside the womb (uterus) that will not develop into a baby. It happens due to a problem with conception, when an egg becomes fertilised by sperm. Types of molar pregnancy There are two types of molar pregnancy:.
Patient information leaflet
Klinefelters syndrom
Between 1 in 500 and 1 in 1,000 boys are born with Klinefelter's syndrome (KS). Many people with KS are not diagnosed until they are adults, and it is believed that up to two thirds may never be diagnosed at all. Males with Klinefelter's syndrome have small testicles (testes) which do not produce enough of the male hormone testosterone before.
Vidare läsning och referenser
- cation channel sperm associated 2; MedlinePlus, National Library of Medicine.
- Avidan N, Tamary H, Dgany O, Cattan D, Pariente A, Thulliez M, Borot N, Moati L, Barthelme A, Shalmon L, Krasnov T, Ben-Asher E, Olender T, Khen M, Yaniv I, Zaizov R, Shalev H, Delaunay J, Fellous M, Lancet D, Beckmann JS. CATSPER2, a human autosomal nonsyndromic male infertility gene. Eur J Hum Genet. 2003 Jul;11(7):497-502. doi: 10.1038/sj.ejhg.5200991.
- Luo T, Chen HY, Zou QX, Wang T, Cheng YM, Wang HF, Wang F, Jin ZL, Chen Y, Weng SQ, Zeng XH. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Hum Reprod. 2019 Mar 1;34(3):414-423. doi: 10.1093/humrep/dey377.
- Maurya S, Bhoi NR, Kesari KK, Roychoudhury S, Kumar D. In Silico Analysis of CatSper Family Genes and APOB Gene Regulation in Male Infertility. Adv Exp Med Biol. 2022;1391:323-332. doi: 10.1007/978-3-031-12966-7_18.
- Quill TA, Sugden SA, Rossi KL, Doolittle LK, Hammer RE, Garbers DL. Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14869-74. doi: 10.1073/pnas.2136654100. Epub 2003 Dec 1.
- Zhang Y, Malekpour M, Al-Madani N, Kahrizi K, Zanganeh M, Lohr NJ, Mohseni M, Mojahedi F, Daneshi A, Najmabadi H, Smith RJ. Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. J Med Genet. 2007 Apr;44(4):233-40. doi: 10.1136/jmg.2006.045765. Epub 2006 Nov 10.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
26 Apr 2024 | Senaste versionen
1 Apr 2024 | Ursprungligen publicerad
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