core-binding factor subunit beta
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Den CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF. These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes.
Normal function
Den CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF. These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes.
The presence of CBFβ helps the complex bind to DNA and protects the RUNX protein from being broken down. The function of CBF depends on which RUNX protein it includes. Once bound to DNA, the RUNX1 protein controls the activity of genes involved in the development of blood cells (hematopoiesis). The RUNX2 protein regulates genes important for bone cell development and formation of the skeleton. The RUNX3 protein primarily affects genes involved in the development of nerve cells.
Conditions referring to this gene or chromosome
Other names
CBF-beta
core-binding factor beta subunit
core-binding factor, beta subunit
PEA2-beta
PEBB_HUMAN
PEBP2-beta
PEBP2B
polyomavirus enhancer binding protein 2, beta subunit
polyomavirus enhancer-binding protein 2 beta subunit
SL3-3 enhancer factor 1 beta subunit
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
Related patient information and medicines
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Kan jag ta Alogliptin och Bisoprolol tillsammans?
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Kan jag ta Lion's mane och Matcha tillsammans?
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Patient information leaflet
Kan jag ta Bisoprolol och Trimbow tillsammans?
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Patient information leaflet
Kan jag ta Apixaban och Bisoprolol tillsammans?
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Patient information leaflet
Kan jag ta Royal sun och Shiitake tillsammans?
Both Royal Sun (Agaricus blazei) and Shiitake (Lentinula edodes) mushrooms contain höga nivåer av beta-glucans, which are substances that stimulate the immune system. Taking them together may cause your immune system to become overactive. Both mushrooms can lower blood sugar levels and thin the blood. Taking them together might increase the risk.
Vidare läsning och referenser
- core-binding factor subunit beta; MedlinePlus, National Library of Medicine.
- Eghtedar A, Borthakur G, Ravandi F, Jabbour E, Cortes J, Pierce S, Kantarjian H, Garcia-Manero G. Characteristics of translocation (16;16)(p13;q22) acute myeloid leukemia. Am J Hematol. 2012 Mar;87(3):317-8. doi: 10.1002/ajh.22258. Epub 2012 Jan 7.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001 Feb 15;20(4):723-33. doi: 10.1093/emboj/20.4.723.
- Shigesada K, van de Sluis B, Liu PP. Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11. Oncogene. 2004 May 24;23(24):4297-307. doi: 10.1038/sj.onc.1207748.
- Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8. doi: 10.1038/ng1015. Epub 2002 Nov 18.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
18 aug 2020 | Senaste versionen
1 Nov 2013 | Ursprungligen publicerad
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