Can I take Atorvastatin and Bisoprolol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known direct interaction between atorvastatin and bisoprolol. These two medicines are very commonly prescribed together to manage heart health and blood pressure.
Why this happens
Atorvastatin is a statin used to lower cholesterol, and bisoprolol is a beta-blocker used to manage blood pressure and heart rate. They are processed by different pathways in the body and do not interfere with how the other works.
What you should do
You can safely take these medicines together as prescribed by your doctor. Always inform your healthcare provider if you experience unusual muscle pain (a potential side effect of statins) or an unusually slow heartbeat (a potential side effect of beta-blockers), but these are side effects of the individual drugs rather than an interaction between them.
Important precautions
Pregnancy
You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can harm the developing baby. Use effective contraception while taking it.
Asthma or COPD
Bisoprolol can cause severe breathing difficulties or trigger an asthma attack. Ensure your doctor knows if you have a history of wheezing or lung disease.
Unexplained muscle pain - atorvastatin
Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately, as this can rarely be a sign of serious muscle damage.
Food and drink warnings
Grapefruit juice
Avoid drinking large amounts of grapefruit juice (more than 1.2 litres a day). Grapefruit contains compounds that can increase the level of atorvastatin in your blood, which may increase your risk of side effects like muscle pain or damage.
Alcohol
While moderate drinking is usually fine, be cautious. For atorvastatin, heavy drinking increases the risk of liver problems. For bisoprolol, alcohol can increase the blood-pressure-lowering effect, which might make you feel dizzy or light-headed, especially when you first start the medicine.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
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