major histocompatibility complex, class I, B
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The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Normal function
The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are categorized into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the main genes in MHC class I.
MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by triggering the infected cell to self-destruct.
The HLA-B gene has many possible variations, that result in the production of proteins that differ by changes in at least one protein building block (amino acid). This variety allows each person's immune system to react to a wide range of foreign invaders. Most HLA-B gene alleles are rare, while others do not affect protein function or change the structure of the protein. Hundreds of versions (alleles) of the HLA-B gene are known, each of which is given a particular number (such as HLA-B27). Closely related alleles are categorized together; for example, more than 60 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-B*2763.
Conditions referring to this gene or chromosome
Other names
1B07_HUMAN
HLA class I histocompatibility antigen, B alpha chain
leukocyte antigen B
MHC class I HLA-B heavy chain
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Vidare läsning och referenser
- major histocompatibility complex, class I, B; MedlinePlus, National Library of Medicine.
- Brown MA, Xu H, Li Z. Genetics and the axial spondyloarthritis spectrum. Rheumatology (Oxford). 2020 Oct 1;59(Suppl4):iv58-iv66. doi: 10.1093/rheumatology/keaa464.
- Chung WH, Hung SI. Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis. J Dermatol Sci. 2012 Jun;66(3):190-6. doi: 10.1016/j.jdermsci.2012.04.002. Epub 2012 Apr 11.
- Colbert RA, Tran TM, Layh-Schmitt G. HLA-B27 misfolding and ankylosing spondylitis. Mol Immunol. 2014 Jan;57(1):44-51. doi: 10.1016/j.molimm.2013.07.013. Epub 2013 Aug 30.
- de Menthon M, Lavalley MP, Maldini C, Guillevin L, Mahr A. HLA-B51/B5 and the risk of Behcet's disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum. 2009 Oct 15;61(10):1287-96. doi: 10.1002/art.24642.
- Giza M, Koftori D, Chen L, Bowness P. Is Behcet's disease a 'class 1-opathy'? The role of HLA-B*51 in the pathogenesis of Behcet's disease. Clin Exp Immunol. 2018 Jan;191(1):11-18. doi: 10.1111/cei.13049. Epub 2017 Oct 6.
- Gul A. Pathogenesis of Behcet's disease: autoinflammatory features and beyond. Semin Immunopathol. 2015 Jul;37(4):413-8. doi: 10.1007/s00281-015-0502-8. Epub 2015 Jun 12.
- Kaur G, Mehra N. Genetic determinants of HIV-1 infection and progression to AIDS: immune response genes. Tissue Antigens. 2009 Nov;74(5):373-85. doi: 10.1111/j.1399-0039.2009.01337.x. Epub 2009 Sep 18.
- Khan MA, Mathieu A, Sorrentino R, Akkoc N. The pathogenetic role of HLA-B27 and its subtypes. Autoimmun Rev. 2007 Jan;6(3):183-9. doi: 10.1016/j.autrev.2006.11.003. Epub 2006 Dec 8.
- Khan MA. An Update on the Genetic Polymorphism of HLA-B*27 With 213 Alleles Encompassing 160 Subtypes (and Still Counting). Curr Rheumatol Rep. 2017 Feb;19(2):9. doi: 10.1007/s11926-017-0640-1.
- Li Z, Brown MA. Progress of genome-wide association studies of ankylosing spondylitis. Clin Transl Immunology. 2017 Dec 1;6(12):e163. doi: 10.1038/cti.2017.49. eCollection 2017 Dec.
- Lopez C, Saravia C, Gomez A, Hoebeke J, Patarroyo MA. Mechanisms of genetically-based resistance to malaria. Gene. 2010 Nov 1;467(1-2):1-12. doi: 10.1016/j.gene.2010.07.008. Epub 2010 Jul 22.
- Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E, Yamakawa R, Yuasa T, Fujioka T, Ohno S, Bahram S, Mizuki N. Genetics of Behcet disease inside and outside the MHC. Ann Rheum Dis. 2010 Apr;69(4):747-54. doi: 10.1136/ard.2009.108571. Epub 2009 Aug 13.
- Navid F, Layh-Schmitt G, Sikora KA, Cougnoux A, Colbert RA. The Role of Autophagy in the Degradation of Misfolded HLA-B27 Heavy Chains. Arthritis Rheumatol. 2018 May;70(5):746-755. doi: 10.1002/art.40414. Epub 2018 Mar 25.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SG. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015 Jan;43(Database issue):D423-31. doi: 10.1093/nar/gku1161. Epub 2014 Nov 20.
- So J, Tam LS. Gut Microbiome and Its Interaction with Immune System in Spondyloarthritis. Microorganisms. 2020 Nov 4;8(11):1727. doi: 10.3390/microorganisms8111727.
- Sousa-Pinto B, Pinto-Ramos J, Correia C, Goncalves-Costa G, Gomes L, Gil-Mata S, Araujo L, Delgado L. Pharmacogenetics of abacavir hypersensitivity: A systematic review and meta-analysis of the association with HLA-B*57:01. J Allergy Clin Immunol. 2015 Oct;136(4):1092-4.e3. doi: 10.1016/j.jaci.2015.03.019. Epub 2015 Apr 29. No abstract available.
- Voruganti A, Bowness P. New developments in our understanding of ankylosing spondylitis pathogenesis. Immunology. 2020 Oct;161(2):94-102. doi: 10.1111/imm.13242. Epub 2020 Aug 17.
- Wallace GR. HLA-B*51 the primary risk in Behcet disease. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8706-7. doi: 10.1073/pnas.1407307111. Epub 2014 May 29. No abstract available.
- Young K, Frodsham A, Doumbo OK, Gupta S, Dolo A, Hu JT, Robson KJ, Crisanti A, Hill AV, Gilbert SC. Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations. Infect Immun. 2005 Feb;73(2):953-5. doi: 10.1128/IAI.73.2.953-955.2005.
Artikelhistorik
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8 Sept 2025 | Senaste versionen
1 mars 2022 | Ursprungligen publicerad
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