phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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Den PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). The p110α protein is called the catalytic subunit because it performs the action of PI3K, while the other subunit (produced by a different gene) regulates the enzyme's activity.
Normal function
Den PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). The p110α protein is called the catalytic subunit because it performs the action of PI3K, while the other subunit (produced by a different gene) regulates the enzyme's activity.
Like other kinases, PI3K adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. PI3K phosphorylates certain signaling molecules, which triggers a series of additional reactions that transmit chemical signals within cells. PI3K signaling is important for many cell activities, including cell growth and division (proliferation), movement (migration) of cells, production of new proteins, transport of materials within cells, and cell survival. Studies suggest that PI3K signaling may be involved in the regulation of several hormones and may play a role in the maturation of fat cells (adipocytes).
Conditions referring to this gene or chromosome
Other names
p110-alpha
phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
phosphoinositide-3-kinase, catalytic, alpha polypeptide
PI3-kinase p110 subunit alpha
PI3K
PI3K-alpha
PK3CA_HUMAN
ptdIns-3-kinase subunit p110-alpha
serine/threonine protein kinase PIK3CA
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Vidare läsning och referenser
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- Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008 May 29;453(7195):662-6. doi: 10.1038/nature06892. Epub 2008 Apr 30.
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18 apr 2023 | Senaste versionen
1 Feb 2020 | Ursprungligen publicerad
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