Can I take Apixaban and Atorvastatin together?

Why this happens

Apixaban and atorvastatin are processed by the same enzyme in the liver (CYP3A4). However, atorvastatin is not a strong enough inhibitor or inducer of this enzyme to change the levels of apixaban in your blood to a degree that would cause concern.

What you should do

You can continue taking both medications as prescribed by your doctor. You do not need to change your routine or dose. As with any blood thinner, you should always watch for signs of unusual bleeding or bruising and report them to your healthcare provider.

Important precautions

Bleeding risk - apixaban

You must seek immediate medical attention if you experience a serious fall or head injury, even if you feel fine, as you are at high risk of internal bleeding. Always inform healthcare professionals, including dentists, that you are taking an anticoagulant before any procedure.

Pregnancy

Do not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. You must use effective contraception while taking it.

Muscle damage - atorvastatin

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately, as this can rarely lead to serious kidney problems.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the level of atorvastatin in your blood, which may increase the risk of side effects like muscle pain. Avoid drinking large quantities (more than 1.2 litres per day), though a small glass is usually fine.

Alcohol

While there is no direct interaction, drinking large amounts of alcohol can increase the risk of liver problems with atorvastatin and increase the risk of stomach bleeding while taking apixaban. It is best to keep to moderate limits.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.