Can I take Aspirin and Naproxen together?

Why this happens

Both drugs belong to the same family (NSAIDs) and work by blocking enzymes called COX-1 and COX-2. When used together, they have an 'additive' effect on the stomach lining, making it much more vulnerable to damage. Furthermore, naproxen can physically block the spot where aspirin needs to attach to your blood cells (platelets), preventing aspirin from thinning the blood properly.

What you should do

You should not take these two medicines together unless specifically instructed and monitored by your doctor. If you require pain relief while taking aspirin, paracetamol is generally a safer alternative. If your doctor has prescribed both, watch for signs of stomach bleeding, such as black tarry stools, coughing up blood, or severe stomach pain.

Important precautions

Asthma

Do not take these medicines if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as they can trigger a life-threatening asthma attack.

Stomach ulcers or bleeding

These medicines significantly increase the risk of stomach ulcers and internal bleeding. Avoid them if you have a history of stomach ulcers or are taking other blood-thinning medications.

Pregnancy (third trimester)

Do not take these medicines if you are more than 28 weeks pregnant, as they can cause serious heart and kidney problems in the unborn baby and complications during delivery.

Food and drink warnings

Alcohol

Drinking alcohol while taking these medicines increases the risk of irritation and bleeding in your stomach and intestines. It is best to limit or avoid alcohol while taking these medications, especially if you take them regularly.

Caffeine

Aspirin can increase the effects of caffeine. Additionally, both aspirin and caffeine can irritate the stomach lining, so consuming large amounts of caffeine (coffee, tea, energy drinks) while taking aspirin may increase your risk of indigestion or stomach upset.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.