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Can I take Aspirin and Paracetamol together?

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Taking aspirin and paracetamol together is generally considered safe for most people. There is no significant evidence that they interfere with how each other is absorbed or processed by the body. In fact, they are often found combined in 'extra strength' over-the-counter cold and flu remedies or migraine tablets. However, because both drugs can affect the stomach and kidneys, taking them together for a long time or in high doses may slightly increase the risk of side effects compared to taking just one.

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Varför detta händer

Aspirin and paracetamol work in different ways to relieve pain. Aspirin is an anti-inflammatory (NSAID) that blocks certain enzymes (COX-1 and COX-2) throughout the body, while paracetamol is thought to work mainly within the central nervous system. Because they use different pathways, they do not 'compete' with each other, but their pain-relieving effects can add together (an additive effect).

It is fine to take these two medicines together for short-term pain relief (such as a headache or fever). Always follow the dosage instructions on the packaging and do not exceed the maximum daily dose for either. If you have a history of stomach ulcers, kidney problems, or asthma, or if you are already taking daily low-dose aspirin for your heart, speak to a pharmacist or doctor before combining them.

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Children under 16 years old

Never give aspirin to children under 16 unless prescribed by a doctor, as it can cause Reye’s syndrome, a rare but life-threatening condition affecting the brain and liver.

Astma

Aspirin can trigger severe asthma attacks or worsening of breathing symptoms in some people with asthma. Do not use if you have a history of aspirin-sensitive asthma.

Liver disease or heavy alcohol use

Paracetamol is processed by the liver; taking more than the recommended dose, or taking it if you have existing liver damage, can cause fatal liver failure. Always check other medicines (like cold and flu remedies) to ensure you are not doubling up on paracetamol.

Alkohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it altogether if you have a history of stomach issues. You should avoid drinking large amounts of alcohol while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take more than the recommended dose of paracetamol.

Caffeine

Aspirin is sometimes combined with caffeine in 'extra power' painkillers. However, if you are taking aspirin for heart health, be aware that high levels of caffeine can increase blood pressure and may slightly increase the risk of stomach irritation.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 24 jan 2026 | Ursprungligen publicerad
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