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Can I take Black cohosh and Solifenacin together?

Guide för läkemedelsinteraktioner

Taking black cohosh and solifenacin together may increase the risk of side effects such as a dry mouth, blurred vision, constipation, or feeling overheated. There is also a small possibility that black cohosh could affect how your liver breaks down solifenacin, potentially leading to higher levels of the medicine in your body.

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Varför detta händer

Both substances can have 'anticholinergic' effects (blocking a specific chemical messenger in the body), which can lead to additive side effects. Additionally, some studies suggest black cohosh may interfere with liver enzymes (specifically CYP3A4) that are responsible for clearing solifenacin from your system.

Use this combination with caution. If you decide to take both, monitor yourself closely for increased side effects like severe constipation, difficulty urinating, or extreme dry mouth. It is best to inform your doctor or pharmacist before starting black cohosh if you are already prescribed solifenacin for overactive bladder.

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Graviditet

Do not use black cohosh during pregnancy. It may stimulate uterine contractions, potentially increasing the risk of miscarriage or premature labour.

Liver disease

Black cohosh has been linked to rare but serious cases of liver failure. You must stop taking it and see a doctor immediately if you develop yellowing of the skin or eyes, dark urine, or severe stomach pain.

Hormone-sensitive conditions (e.g. breast cancer)

Because black cohosh may act like the hormone oestrogen, you should not use it if you have a history of breast cancer, uterine cancer, or endometriosis without specialist medical supervision.

Glaucoma

Do not take solifenacin if you have narrow-angle glaucoma, as it can increase the pressure in your eyes and cause a medical emergency.

Urinary retention or Gastric retention

Do not use solifenacin if you have severe difficulty passing urine or if your stomach empties very slowly, as it can worsen these blockages.

Alkohol

Black cohosh has been linked to rare but serious cases of liver damage. Because alcohol also puts strain on the liver, it is advisable to limit or avoid alcohol consumption while taking this supplement to reduce the risk of liver toxicity.

Solifenacin can cause sleepiness and blurred vision. Drinking alcohol while taking this medicine may increase these effects, making you feel more drowsy or dizzy. It is best to limit your alcohol intake until you know how the medicine affects you.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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