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Can I take Cannabis and Ibuprofen together?

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Using cannabis and ibuprofen together may increase the risk of side effects such as stomach irritation, indigestion, or a higher risk of bleeding. It may also increase the chance of feeling dizzy, drowsy, or confused.

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If you have a diagnosed condition and standard treatments haven’t worked, you may be eligible for specialist-prescribed medical cannabis in the UK. Kontrollera din behörighet

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Varför detta händer

Both substances can affect the lining of the stomach and how blood clots (pharmacodynamic effect). Additionally, cannabis may slow down the liver's ability to process certain non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, potentially leading to higher levels of the medicine in your system (pharmacokinetic effect).

Use caution when combining these two. If you need to take them together, use the lowest dose of ibuprofen possible for the shortest time. Watch for signs of stomach pain, dark stools, or unusual bruising. If you feel excessively dizzy or sleepy, avoid driving or operating machinery.

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Astma

Do not take ibuprofen if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a severe or life-threatening asthma attack.

Stomach ulcers or bleeding

Do not take ibuprofen if you have a history of stomach ulcers, perforation, or bleeding, as it significantly increases the risk of serious gastrointestinal bleeding.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant (third trimester), as it can cause serious heart and kidney problems in the unborn baby and complications during delivery.

Psychosis or Schizophrenia

You must not use cannabis if you have a personal or strong family history of schizophrenia or other psychotic disorders, as it can trigger or worsen these conditions.

Driving and operating machinery

It is an offence to drive if your ability is impaired by cannabis. Even if you do not feel 'high', the drug stays in your system and can result in a drug-driving conviction.

Alkohol

Drinking alcohol while using cannabis can significantly increase the sedative effects, leading to extreme drowsiness, dizziness, and impaired coordination. It may also increase the levels of THC in your blood, making the 'high' more intense or unpredictable.

Grapefruit juice

Grapefruit and grapefruit juice can interfere with how your body breaks down certain compounds in cannabis (particularly CBD). This can lead to higher levels of the medicine in your system, potentially increasing side effects.

Fatty meals

If you are taking cannabis in oral forms (like oils or capsules), eating a high-fat meal can significantly increase the amount of the drug absorbed into your system. This can make the effects much stronger than usual. It is best to be consistent with how you take it in relation to food.

Food (General)

While not an interaction that changes how the drug works, it is strongly recommended to take ibuprofen with food or a glass of milk to protect your stomach lining and reduce the risk of indigestion.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

Sponsrad

Kan medicinsk cannabis vara ett alternativ för dig?

If you have a diagnosed condition and standard treatments haven’t worked, you may be eligible for specialist-prescribed medical cannabis in the UK. Kontrollera din behörighet

Fortsätt läsa nedan

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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