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Can I take Codeine and Ibuprofen together?

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There is no harmful interaction between codeine and ibuprofen. In fact, they are often taken together because they work in different ways to provide better pain relief than either medicine alone.

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Varför detta händer

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation at the site of injury. Codeine is an opioid that works in the brain and spinal cord to change how your body feels and responds to pain. Because they target pain through different pathways, their effects are additive.

It is safe to take these together, provided you do not exceed the recommended dose for either medication. Be aware that many "plus" or "extra" branded painkillers already contain both ingredients (such as Nurofen Plus), so always check the packaging to avoid accidentally taking a double dose. Common side effects when taking both may include constipation or an upset stomach.

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Astma

Do not take codeine or ibuprofen if you have asthma, as they can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Addiction and Dependency

Codeine contains an opioid which can cause addiction if used for more than 3 days. Long-term use can lead to withdrawal symptoms when you stop.

Breastfeeding

Do not take codeine while breastfeeding. It passes into breast milk and can cause life-threatening breathing problems or extreme sleepiness in your baby.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Stomach Ulcers or Bleeding

Avoid ibuprofen if you have ever had a stomach ulcer or gastrointestinal bleeding, as it can cause serious internal bleeding or perforation.

Alkohol

You must avoid drinking alcohol while taking codeine. Both alcohol and codeine are central nervous system depressants. Combining them significantly increases the risk of severe drowsiness, dizziness, and dangerous breathing problems (respiratory depression).

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

Food (General)

You should ideally take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduces the chance of indigestion or stomach upset.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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