Can I take Naproxen and Pregabalin together?

Why this happens

Both medications can affect the central nervous system, leading to an 'additive' effect on sleepiness. Additionally, both drugs can independently cause the body to hold onto extra fluid, which may increase the risk of swelling (oedema).

What you should do

It is generally safe to take these together if prescribed by your doctor, but you should be cautious. Avoid driving or operating machinery until you know how the combination affects you. If you notice significant swelling in your ankles or hands, or if you feel unusually dizzy, contact your GP.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Asthma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Stomach ulcers or bleeding

Naproxen can cause serious stomach ulcers and internal bleeding. This risk is higher if you have had ulcers before, are over 65, or take other blood-thinning medicines. Stop taking it and see a doctor immediately if you have black, tarry stools or vomit blood.

Drug dependence and misuse

Pregabalin is a controlled drug that carries a risk of addiction and dependence. It can cause dangerous breathing problems if taken with other sedatives or opioids.

Pregnancy

Pregabalin use during the first three months of pregnancy may increase the risk of birth defects. Effective contraception must be used during treatment.

Pregnancy (third trimester)

Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking naproxen. Both alcohol and naproxen can irritate the lining of your stomach; combining them significantly increases your risk of developing stomach ulcers or internal bleeding.

It is best to avoid or strictly limit alcohol while taking pregabalin. Combining alcohol with this medicine can significantly increase side effects such as extreme sleepiness, dizziness, and blurred vision. It can also increase the risk of breathing problems.

Food (General)

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.