Hoppa till huvudinnehåll

Can I take Colecalciferol and Esomeprazole together?

Guide för läkemedelsinteraktioner

There is no evidence of a harmful interaction between colecalciferol (Vitamin D3) and esomeprazole. In fact, taking them together may be beneficial for your bone health.

Video picks for Läkemedelsinteraktioner

Fortsätt läsa nedan

Varför detta händer

Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid. Long-term use of PPIs can sometimes interfere with the absorption of certain minerals like calcium. Colecalciferol helps your body absorb calcium more effectively, which can help counteract the potential bone-thinning effects associated with long-term esomeprazole use.

You can safely take these two medications together. You do not need to space them apart or change the time of day you take them. If you are taking esomeprazole for a long period, it is actually quite common for doctors to recommend a Vitamin D supplement like colecalciferol to protect your bones.

Fortsätt läsa nedan

Severe diarrhoea or stomach pain

Esomeprazole can increase your risk of developing a serious bowel infection called Clostridium difficile. If you develop severe, watery, or bloody diarrhoea, seek medical advice immediately.

Hyperkalcemi (högt kalcium i blodet)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium absorption and can worsen these conditions.

Low magnesium levels (hypomagnesaemia)

Taking esomeprazole for more than 3 months can cause your blood magnesium levels to drop. This is particularly dangerous if you are already taking magnesium supplements or medicines like digoxin, as it can lead to severe fatigue, muscle spasms, or an irregular heartbeat. Your doctor may need to monitor your levels via blood tests.

Alkohol

It is best to avoid or strictly limit alcohol while taking colecalciferol. Long-term heavy alcohol use can interfere with how your body absorbs and processes Vitamin D, making the treatment less effective.

It is best to avoid or strictly limit alcohol while taking esomeprazole. Alcohol can increase the amount of acid your stomach produces, which may worsen your symptoms or make the medicine less effective. Additionally, both alcohol and esomeprazole can irritate the stomach lining.

Caffeine (Coffee, tea, energy drinks)

Caffeine can increase stomach acid production and may trigger or worsen symptoms of acid reflux and heartburn, potentially counteracting the benefits of esomeprazole.

Fettrika måltider

Colecalciferol is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Fortsätt läsa nedan

Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

Fortsätt läsa nedan

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
flu eligibility checker

Fråga, dela, anslut.

Bläddra i diskussioner, ställ frågor och dela erfarenheter inom hundratals hälsorelaterade ämnen.

symptom checker

Känner du dig sjuk?

Bedöm dina symtom online gratis

Anmäl dig till Patientens nyhetsbrev

Din veckovisa dos av tydliga, pålitliga hälsoråd - skrivna för att hjälpa dig känna dig informerad, självsäker och i kontroll.

Vänligen ange en giltig e-postadress

By subscribing you accept our Sekretesspolicy. Du kan avsluta prenumerationen när som helst. Vi säljer aldrig dina uppgifter.