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Can I take Estradot and Hormone replacement together?

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Estradot is a brand name for a type of Hormone Replacement Therapy (HRT) containing oestradiol. Taking Estradot alongside other HRT medications that contain oestrogen is essentially taking a double dose of the same medication. This can lead to an overdose of oestrogen, causing side effects like breast tenderness, nausea, headaches, and an increased risk of blood clots.

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Varför detta händer

Estradot and other oestrogen-based HRT products have 'additive' effects. Because they contain the same or similar active ingredients, using them together increases the total amount of hormone in your bloodstream beyond the recommended therapeutic level.

Do not use Estradot with any other oestrogen-containing HRT unless specifically instructed by a specialist. If you are already using an HRT patch, gel, or tablet, speak to your doctor or pharmacist before starting Estradot to ensure you are not duplicating your treatment.

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History of blood clots (VTE) or breast cancer

You must not use this treatment if you have ever had a blood clot in a vein (thrombosis), a pulmonary embolism, or if you have ever had breast cancer, as HRT can significantly increase the risk of these conditions recurring.

Intact uterus (womb)

If you still have your womb, using Estradot (oestrogen) alone increases the risk of cancer of the womb lining. You must also take a progestogen medicine to protect your womb lining unless you have had a hysterectomy.

Application site selection

Never apply the patch on or near the breasts. It should only be applied to the lower body (usually the buttocks or hips) to avoid increasing the risk of breast-related complications.

Grapefruit juice

Grapefruit juice can interfere with the enzymes that break down oestrogen in your body. This may lead to higher levels of the hormone in your bloodstream, potentially increasing the risk of side effects like breast tenderness, nausea, or bloating. While a small amount is unlikely to cause harm, it is best to avoid consuming large quantities.

Alkohol

Drinking alcohol while using HRT can cause a temporary spike in your oestrogen levels. Long-term, heavy alcohol consumption combined with HRT may also slightly increase the risk of breast cancer compared to HRT use alone. It is advisable to stay within the recommended UK low-risk drinking guidelines (no more than 14 units per week).

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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