Can I take Maitake and Reishi together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking maitake and reishi together may increase the risk of bruising or bleeding. Both mushrooms have properties that can slow down blood clotting. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both maitake and reishi have 'antiplatelet' effects, meaning they make blood cells less sticky and less likely to form clots. When used together, this effect is additive. They also both possess glucose-lowering properties, which can further reduce blood sugar levels when combined.
What you should do
It is generally safe for healthy individuals to take these together in moderate amounts, but you should use caution. If you are scheduled for surgery, stop taking both at least two weeks beforehand. If you take blood-thinning medications (like warfarin or aspirin) or diabetes medication, speak to your doctor before combining these supplements, as your dosages may need adjusting.
Important precautions
Bleeding disorders or surgery
Both maitake and reishi may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.
Diabetes
These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).
Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Low blood pressure (Hypotension)
These supplements may lower blood pressure. If you already have low blood pressure or take medication to control high blood pressure, they could cause your blood pressure to drop too low.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Maitake and Reishi can have effects on the liver, and combining them with alcohol may increase the risk of liver strain or damage. Additionally, Reishi can have sedative effects which alcohol may intensify.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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