Can I take Naproxen and Omeprazole together?

Why this happens

Omeprazole reduces stomach acid, which can slightly slow down the rate at which naproxen dissolves and enters the blood. However, it does not change the total amount of naproxen that your body receives. This is a beneficial interaction because omeprazole protects the stomach lining from the irritating effects of naproxen.

What you should do

It is safe and often recommended to take these two medicines together. You should follow your doctor's instructions on when to take each one. Usually, omeprazole is taken in the morning on an empty stomach, while naproxen should be taken with or after food to further protect your stomach.

Important precautions

Asthma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Stomach ulcers or bleeding

Naproxen significantly increases the risk of stomach ulcers and internal bleeding. Omeprazole is often prescribed alongside it to reduce this risk, but you must seek immediate medical help if you pass black, tarry stools or vomit blood.

Pregnancy (third trimester)

Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Severe diarrhoea

Contact your doctor immediately if you develop severe or persistent watery diarrhoea, as omeprazole can increase the risk of a serious bowel infection called Clostridium difficile.

Food and drink warnings

Alcohol

Drinking alcohol while taking naproxen can increase the risk of irritation to your stomach lining and may increase the risk of stomach ulcers or bleeding. It is best to limit or avoid alcohol while taking this medicine.

It is best to avoid or strictly limit alcohol while taking omeprazole. Alcohol can increase the amount of acid your stomach produces, which may worsen your symptoms or make the medicine less effective. Additionally, both alcohol and omeprazole can irritate the stomach lining.

Food (General)

You should take naproxen with or after food. This helps to protect your stomach lining and reduces the chance of side effects like indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.