Can I take Losartan and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Why this happens
Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin D is a fat-soluble vitamin. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.
What you should do
You can continue to take both as prescribed. It is always a good idea to have your blood pressure and kidney function monitored regularly by your doctor while taking losartan, regardless of vitamin D use.
Important precautions
Pregnancy
You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.
Hypercalcaemia (high blood calcium)
Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.
Potassium-rich foods (e.g., bananas, spinach, salt substitutes)
Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.
High-fat meals
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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