Can I take Losartan and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Why this happens
Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin D is a fat-soluble vitamin. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.
What you should do
You can continue to take both as prescribed. It is always a good idea to have your blood pressure and kidney function monitored regularly by your doctor while taking losartan, regardless of vitamin D use.
Important precautions
Pregnancy
You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.
Hypercalcaemia (high blood calcium)
Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.
Potassium-rich foods (e.g., bananas, spinach, salt substitutes)
Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.
High-fat meals
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Mounjaro and Paracetamol together?
Mounjaro may slow down how quickly your body absorbs paracetamol. This means it might take longer for the paracetamol to start working to relieve pain or reduce a fever. However, the total amount of medicine that gets into your system should remain the same.

Drug interactions checker
Can I take Warfarin and Aspirin together?
Taking warfarin and aspirin together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, as well as bleeding that is hard to stop from minor cuts or injuries.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amlodipine and Citalopram together?
- Can I take Atorvastatin and Reishi together?
- Can I take Bisoprolol and Metformin together?
- Can I take Black cohosh and Vitamin D together?
- Can I take Calcium and Ciprofloxacin together?
- Can I take Candesartan and Mirtazapine together?
- Can I take Clarithromycin and Rosuvastatin together?
- Can I take Clopidogrel and Fenofibrate together?
- Can I take Clopidogrel and Gabapentin together?
- Can I take Cod liver oil and Losartan together?
- Can I take Cordyceps and Royal sun together?
- Can I take Danazol and Sertraline together?
- Can I take Fexofenadine and Pregabalin together?
- Can I take Lercanidipine and Pregabalin together?
- Can I take Magnesium and Bisoprolol together?
- Can I take Magnesium and Sertraline together?
- Can I take Morphine and Solifenacin together?
- Can I take Omeprazole and Paracetamol together?
- Can I take Warfarin and Paracetamol together?