Can I take Omeprazole and Vitamin D together?

Why this happens

Omeprazole reduces stomach acid, which can sometimes affect how certain nutrients are absorbed. However, vitamin D does not require a highly acidic environment for the body to process it effectively. There are no known issues with how the liver or kidneys handle these two substances at the same time.

What you should do

You can continue taking both as prescribed. To help your body absorb vitamin D better, it is best to take your vitamin D supplement with a meal that contains some fat (such as yoghurt, eggs, or avocado), as vitamin D is fat-soluble.

Important precautions

Severe diarrhoea

Contact your doctor immediately if you develop severe or persistent watery diarrhoea, as omeprazole can increase the risk of a serious bowel infection called Clostridium difficile.

Vitamin B12 deficiency

Long-term use of omeprazole can prevent your body from absorbing Vitamin B12 properly, which may lead to nerve damage or anaemia.

Hypercalcaemia (high blood calcium)

Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking omeprazole. Alcohol can increase the amount of acid your stomach produces, which may worsen your symptoms or make the medicine less effective. Additionally, both alcohol and omeprazole can irritate the stomach lining.

General Food Timing

Omeprazole works best if you take it 30 to 60 minutes before a meal, preferably breakfast. Taking it with food can slow down how quickly the medicine starts to work.

High-fat meals

Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as dairy, eggs, or avocado).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.