Gliclazide
Diamicron, Zicron
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 27 Sept 2022
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Take gliclazide with your breakfast.
Remember to follow any advice you have been given about what you should or shouldn't eat, and try to take some regular exercise.
Make sure you know how to recognise the symptoms of low blood sugar. These include feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy.
Överblick
Gliclazide is a medicine for type 2 diabetes that increases insulin production.
It helps control blood sugar levels, reducing the risk of complications.
Take gliclazide once a day with breakfast, unless advised otherwise by your doctor.
Understand the signs of low blood sugar (a 'hypo') and how to treat them.
Common side-effects include feeling sick, indigestion, and diarrhoea.
About gliclazide
Typ av medicin | Sulfonylurea antidiabetic medicine |
Används för | Type 2 diabetes mellitus |
Även kallad | Dacadis® MR, Diamicron®, Edicil® MR, Glydex®, Laaglyda® MR, Lamzarin®, Nazdol® MR, Zicron®, Ziclaseg® |
Tillgänglig som | Tablets and modified-release (MR) tablets |
Insulin is a hormone that is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin to meet its needs, or if it does not use the insulin it makes effectively, this results in the condition called diabetes (diabetes mellitus).
People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar (glucose) reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but for other people, medicines like gliclazide are given alongside the changes in diet.
Gliclazide works by increasing the amount of insulin that your pancreas produces. It can be given on its own or alongside other antidiabetic medicines or insulin.
Before taking gliclazide
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking gliclazide it is important that your doctor or pharmacist knows:
Om du är gravid, försöker bli gravid eller ammar.
If you have kidney or liver problems.
If you have been told you have porphyria or glucose 6-phosphate dehydrogenase (G6PD) deficiency. These are rare inherited disorders.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take gliclazide
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about gliclazide and a full list of side-effects which you may experience from taking it.
Take gliclazide exactly as your doctor has told you. It is usually recommended that you take it once a day with breakfast. Some people who need to take higher doses may be asked to split their dose and take tablets twice a day. Your doctor or pharmacist will tell you which is right for you, and your dose will also be on the label of the pack to remind you.
If you have been given a modified-release form of gliclazide tablet (these usually have 'MR' after the tablet name), they should be swallowed whole. Do not break or crush the tablets, as they are specially coated to allow the medicine to be released slowly and evenly over the day.
If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose - do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
It is important that you keep your regular doctor's and clinic appointments. This is so your progress can be monitored. You are likely to need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic.
Your doctor may recommend that you test for sugar (glucose) in your blood regularly to check that your diabetes is being controlled. Your doctor or diabetes nurse will show you how to do this.
If you have been given advice by your doctor about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given.
Make sure you know what it feels like if your blood sugar is too low. This is known as hypoglycaemia, or a 'hypo'. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, or sugary sweets or drinks (non-diet), and then follow this up with a snack such as a sandwich or a banana.
Hypoglycaemia may occur if you miss a meal, if you exercise more than usual, if you are ill, or if you drink a lot of alcohol.
If you are a driver you should take special care, as your ability to concentrate may be affected if your diabetes is not well controlled. You may be advised to check your blood sugar levels before you travel and to have a snack with you on long journeys.
Drivers in the UK may need to inform the Driver and Vehicle Licensing Agency (DVLA) if they experience an episode of severe hypoglycaemia or experience a 'hypo' whilst driving. Ask your doctor for advice. Drivers in other countries should contact the relevant vehicle licensing agency.
Check with your doctor before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood levels more regularly.
Drinking alcohol is not advisable with gliclazide. If you do have a drink, keep well within the recommended alcohol limits, as alcohol will affect the control of your blood sugar.
If you become unusually thirsty, pass urine more frequently, and feel very tired, then let your doctor know. Your dose of gliclazide may need adjusting.
Treatment for diabetes is lifelong. Continue to take the tablets unless you are advised otherwise by your doctor.
If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and are taking gliclazide.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines may interfere with gliclazide.
Can gliclazide cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with gliclazide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.
Common gliclazide side-effects | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting), indigestion | Stick to simple meals - avoid rich or spicy food. Make sure you take your tablets after you have eaten something |
Loose, watery stools (diarrhoea) | Drick mycket vatten för att ersätta förlorade vätskor |
Förstoppning | Eat a well-balanced diet and drink plenty of water |
Increased weight | Eat a well-balanced diet but continue to eat regularly - do not skip meals |
Signs of low blood sugar : feeling shaky or anxious, sweating, looking pale, feeling hungry, feeling that your heart is pounding (palpitations), feeling dizzy | Eat something containing sugar, such as a biscuit or a sugary drink (not diet), and follow this up with a snack such as a sandwich. Tell your doctor if you notice these symptoms |
Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.
How to store gliclazide
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå omedelbart till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
When is the best time to take gliclazide?
Gliclazide is usually recommended to be taken once a day with breakfast. However, for higher doses, some people may need to split their dose and take tablets twice a day. Your doctor or pharmacist will specify the correct timing and dosage for you.
What should I do if I forget to take a dose of gliclazide?
If you remember on the same day, take the missed dose as soon as you recall. If you don't remember until the following day, skip the missed dose and continue with your regular schedule. Do not take two doses together to compensate for a forgotten dose.
What kind of monitoring should I expect while taking gliclazide?
It's important to keep your regular doctor's and clinic appointments to monitor your progress. You will likely need regular check-ups with an eye clinic, a foot clinic, and your diabetes clinic. Your doctor may also suggest regularly testing your blood sugar to ensure your diabetes is well-controlled.
Are there any activities I should be careful with or avoid while taking gliclazide?
Yes, exercise can affect your blood sugar levels, so check with your doctor before starting any new physical activity. If you drive, be aware that your concentration may be affected if your diabetes is not well controlled, and you may need to check your blood sugar levels before long journeys. It is also advisable to limit alcohol consumption and stay within recommended limits as it can impact blood sugar control.
What should I do if my blood sugar levels are too low (hypoglycaemia)?
If you experience symptoms of low blood sugar, such as feeling shaky, anxious, sweating, looking pale, hunger, palpitations, or dizziness, you should immediately eat something sugary like dextrose tablets, sugary sweets, or a non-diet drink. Follow this up with a snack like a sandwich or a banana. Inform your doctor if you frequently experience these symptoms.
What should I do if I notice I am unusually thirsty, urinating more frequently, and feeling very tired?
These symptoms could indicate that your dose of gliclazide may need adjusting. You should let your doctor know about these changes so they can assess your condition and make any necessary modifications to your treatment.
Why is it important to tell my doctor or dentist that I'm taking gliclazide before an operation or dental treatment?
It is important to inform the person carrying out the treatment that you have diabetes and are taking gliclazide to ensure your medical care is appropriately managed. Diabetes and certain medications can affect how you respond to procedures and anaesthesia, so informing your healthcare provider helps them plan your treatment safely.
Vidare läsning och referenser
- Manufacturer's PIL, Diamicron® 30 mg MR Tablets; Servier Laboratories Limited, The electronic Medicines Compendium. Dated July 2022.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
- Manufacturer's PIL, Gliclazide 80 mg tablets; Accord-UK Ltd, electronic Medicines Compendium. Dated March 2021
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 25 Mar 2027
27 Sept 2022 | Senaste versionen

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