Sertraline
Contulen, Lustral, Zoloft
Granskad av Dr Colin Tidy, MRCGPSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 30 Aug 2023
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Try to take sertraline at the same time each day.
It may take up to four weeks after starting this treatment before you feel the full benefit. Do not stop taking it, even if you feel like it is not helping.
Common side effects of sertraline include feeling sick (nausea), headache, trouble sleeping, diarrhoea, and feeling dizzy, tired or weak.
Tell your doctor if you feel that you are not getting any better, or if you experience any troublesome side effects.
Överblick
Sertraline is an antidepressant used to treat depression, anxiety disorders, and obsessive-compulsive disorder.
Common side effects include feeling sleepy, sick, headaches, and mood changes.
Do not drive or use machines if you feel sleepy, dizzy, or weak after taking it.
Sertraline usually takes one to two weeks to start working and four to six weeks for the full benefit.
Do not drink grapefruit juice or alcohol, and avoid St John's wort while taking sertraline.
Contact your doctor if you have thoughts of harming yourself or an allergic-type reaction.
Never stop taking sertraline suddenly; your doctor will advise on gradually reducing the dose.
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About sertraline
Typ av medicin | A selective serotonin reuptake inhibitor (SSRI) antidepressant |
Används för | Depression, and anxiety disorders (such as panic disorder, social anxiety disorder, post-traumatic stress disorder), and obsessive-compulsive disorder (OCD) |
Also called (UK) | Contulen®; Lustral® |
Also called (USA) | Zoloft® |
Tillgänglig som | Tablets, oral liquid medicine (USA) |
Dosage | 50 mg, 100mg |
What is sertraline used for?
Tillbaka till innehållSertraline is a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). It is used to treat depression, anxiety disorders, and obsessive-compulsive disorder.
SSRIs like sertraline increase the amount of circulating serotonin available in your brain. This can help improve symptoms of depression, anxiety disorders, and OCD.
An anxiety disorder is a condition where anxiety is a major symptom. Panikstörning, social anxiety disorder, och post-traumatic stress disorder are all anxiety disorders. OCD is a condition where you have recurring and persistent ideas that make you do repetitive actions.
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Side effects of sertraline
Tillbaka till innehållThe most common side effects of sertraline are:
Feeling sleepy, dizzy or weak.
Feeling sick or being sick (vomiting).
Förstoppning eller diarré.
Huvudvärk.
Mood changes such as feeling anxious, nervous or agitated.
Feeling restless or shaky.
Flushing and sweating.
Torr mun.
Difficulty sleeping and bad dreams.
Sore throat.
Tingling feelings.
Lack of concentration.
Synproblem.
Yawning.
Swallowing problems.
Reduced sexual drive (libido).
Changes in appetite.
Allmänna värk och smärtor.
Du hittar en fullständig lista i tillverkarens informationsblad som medföljer din medicin. De oönskade effekterna förbättras ofta när din kropp anpassar sig till den nya medicinen, men tala med din läkare eller apotekare om något av följande fortsätter eller blir besvärligt.
How to manage sertraline side effects
Tillbaka till innehållCommon sertraline side effects | Vad kan jag göra om jag upplever detta? |
Feeling sleepy, dizzy or weak | If this happens, do not drive and do not use tools or machines |
Feeling sick or being sick, constipation or diarrhoea, indigestion | Håll dig till enkel mat |
Huvudvärk | Drick mycket vatten och be din apotekare rekommendera en lämplig smärtstillande. Om huvudvärken fortsätter, informera din läkare |
Mood changes such as feeling anxious, nervous or agitated. Feeling restless or shaky | This may happen when you first start taking sertraline but it usually settles within a few days. If it becomes troublesome or severe, speak with your doctor |
Dry mouth, difficulty sleeping, bad dreams, sore throat, tingling feelings, lack of concentration, eyesight problems, ringing noises, flushing, sweating, yawning, reduced sexual drive or ability, change in appetite, aches or pains, swallowing problems | Prata med din läkare om något av detta blir besvärligt |
Viktigt: a few people taking sertraline have developed an allergic-type reaction. You should contact your doctor straightaway if you develop any swelling around your face, any difficulties breathing, or a severe rash.
On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Stiff muscles or 'jerky' movements.
Unusually fast heartbeat.
High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.
Feeling delirious or seeing visions (hallucinating).
If you experience any other symptoms that you think may be due to this medicine, speak with your doctor or pharmacist for further advice.
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Who should not take sertraline?
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sertraline it is important that your doctor knows:
Om du är gravid, försöker bli gravid eller ammar.
If you have a heart condition, or a liver or kidney disorder.
If you have epilepsy.
If you have high blood sugar levels (diabetes mellitus).
If you have an eye problem called glaucoma.
If you have ever had a bleeding disorder.
If you have ever had abnormally 'high' moods, called mania.
If you are being treated with electroconvulsive therapy (ECT).
Om du någonsin har haft en allergisk reaktion mot en medicin.
If you have taken an antidepressant known as a monoamine-oxidase inhibitor (MAOI) within the previous two weeks.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to take sertraline
Tillbaka till innehållRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about sertraline and will provide you with a full list of the side effects which you may experience from taking it.
Take sertraline exactly as your doctor tells you to - it is taken once daily. Most doctors recommend that it is taken either in the morning eller in the evening. Try to take your doses at the same time of day each day.
There are two strengths of tablet available - 50 mg and 100 mg. Your doctor will tell you which strength is right for you.
If you are being treated for an anxiety disorder, your doctor may prescribe a low dose for you to begin with, and then gradually increase it. This is because slowly increasing the dose helps to reduce the risk of side effects.
You can take sertraline before or after food.
If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
Getting the most from sertraline
Tillbaka till innehållFörsök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
If you buy any medicines, check with a pharmacist that they are safe to take with sertraline. This is because several medicines which are available from general retail outlets can interfere with this treatment.
In particular, do not take the herbal remedy St John's wort, and ask for advice before buying any anti-inflammatory painkillers.
While you are taking sertraline, you may have thoughts about harming yourself or ending your life. These thoughts may also be associated with your condition. It is very important that you tell your doctor about this if it happens.
Do not stop taking sertraline unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
You should expect that a course of treatment will last for several months. This is normal and helps to prevent your symptoms from recurring.
If you have diabetes, you may need to check your blood glucose more frequently, as sertraline may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
A few people taking sertraline find that their skin is more sensitive to sunlight than normal. Until you know how your skin reacts, use a sun cream with a high sun protection factor (SPF) in strong sunlight.
There are several types of antidepressants and they differ in their possible side effects. If you find that sertraline does not suit you then let your doctor know, as another may be found that will.
How to store sertraline
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.
Vanliga frågor
Tillbaka till innehållHow long does sertraline take to work?
Sertraline can take a week or two before the effect begins to build up, and 4-6 weeks before you feel the full benefit of it working. Do not stop taking it even if you feel like it is not helping.
Can I drink alcohol when taking sertraline?
Your doctor is likely to recommend that you do not drink alcohol while you are on sertraline, as it increases the risk of side effects, such as feeling sleepy. If you drink alcohol you should ask your doctor for advice.
Can I have grapefruit whilst taking sertraline?
Do not drink grapefruit juice while you are on sertraline. This is because a chemical in grapefruit juice increases the amount of sertraline in your bloodstream. This makes side effects more likely.
When do sertraline side effects start?
Side effects from sertraline often start within the first few days of taking the medicine. Some people may notice them straight away, while others find they appear after a week or so. These effects are usually mild and tend to improve as your body adjusts.

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Vanliga frågor
Can I drive or operate machinery while taking sertraline?
Sertraline can cause you to feel sleepy, dizzy, or weak. If you experience these side effects, it's important not to drive or use tools or machines to ensure your safety and the safety of others.
Will sertraline make me sleepy?
Yes, feeling sleepy is a common side effect of sertraline. Other common side effects include dizziness and weakness.
Do I need to take sertraline with food?
No, you have the flexibility to take sertraline either before or after a meal, according to your preference.
What should I do if I forget a dose of sertraline?
If you miss a dose, take it as soon as you remember. However, if you don't remember until the next day, you should skip the missed dose and continue with your regular schedule. Do not take two doses at once to compensate for the forgotten dose.
Can I stop taking sertraline if I feel better?
No, you should not stop taking sertraline unless your doctor tells you to. Stopping the treatment suddenly can lead to problems. Your doctor will likely want you to gradually reduce your dose when it's appropriate to do so. A course of treatment usually lasts for several months to help prevent your symptoms from returning.
What should I do if I have thoughts of harming myself while taking sertraline?
If you experience thoughts about harming yourself or ending your life while taking sertraline, it is very important to tell your doctor about this immediately. These thoughts can also be associated with your condition.
Vidare läsning och referenser
- Manufacturer's PIL, Lustral® 50 mg and 100 mg tablets; Upjohn UK Limited, The electronic Medicines Compendium. Dated April 2023.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensentenVisa fullständig biografi

Dr Colin Tidy, MRCGP
Allmänläkare, Medicinsk Författare
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy är en NHS-läkare, baserad i Oxfordshire.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 29 Aug 2026
30 Aug 2023 | Senaste versionen

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