Autoimmune Addison disease
Senast uppdaterad 17 Mar 2026
Uppfyller patientens redaktionella riktlinjer
- Ladda nerLadda ner
- Dela
- Language
- Diskussion
- Ljudversion
- Lägg till i föredragna källor på Google
Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.
Beskrivning
Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.
The signs and symptoms of autoimmune Addison disease can begin at any time, although they most commonly begin between ages 30 and 50. Common features of this condition include extreme tiredness (fatigue), nausea, decreased appetite, and weight loss. In addition, many affected individuals have low blood pressure (hypotension), which can lead to dizziness when standing up quickly; muscle cramps; and a craving for salty foods. A characteristic feature of autoimmune Addison disease is abnormally dark areas of skin (hyperpigmentation), especially in regions that experience a lot of friction, such as the armpits, elbows, knuckles, and palm creases. The lips and the inside lining of the mouth can also be unusually dark. Because of an imbalance of hormones involved in development of sexual characteristics, women with this condition may lose their underarm and pubic hair.
Other signs and symptoms of autoimmune Addison disease include low levels of sugar (hypoglycemia) and sodium (hyponatremia) and high levels of potassium (hyperkalemia) in the blood. Affected individuals may also have a shortage of red blood cells (anaemia) and an increase in the number of white blood cells (lymphocytosis), particularly those known as eosinophils (eosinophilia).
Autoimmune Addison disease can lead to a life-threatening adrenal crisis, characterised by vomiting, abdominal pain, back or leg cramps, and severe hypotension leading to shock. The adrenal crisis is often triggered by a stressor, such as surgery, trauma, or infection.
Individuals with autoimmune Addison disease or their family members can have another autoimmune disorder, most commonly autoimmune thyroid disease or type 1 diabetes.
Inheritance patterns
The source lists the following possible inheritance patterns: Pattern unknown. More than one pattern can apply in different cases.
Related genes
Other names
Autoimmune Addison's disease
Autoimmune adrenalitis
Classic Addison disease
Primary Addison disease
Related patient information and medicines
Patient information leaflet
Addisons sjukdom
Add... Addison's disease causes Causes of Addison's disease include: Autoimmun Addison's disease In Western Europe, more than 8 in 10 cases are due to an autoimmune disease. The immune system normally makes proteins called antibodies, which are sent into the bloodstream to attack bacteria, viruses, and other germs. If you have autoimmune.
Patient information leaflet
Nagelpsoriasis
Psoriasis is a persistent (chronic) skin condition which tends to flare up from time to time. About half of the people who have psoriasis also have changes affecting their nails. Psoriasissjukdom i naglar is a type of psoriasis. For example, methotrexate , ciclosporin, acitretin , infliximab, etanercept , efalizumab, ustekinumab eller adalimumab. There.
Patient information leaflet
Sjukdomsmodifierande antireumatiska läkemedel
Disease-modifying antirheumatic drugs (DMARDs) are medicines that are normally prescribed as soon as rheumatoid arthritis (RA) is diagnosed, in order to reduce damage to the joints. Disease-modifying antirheumatic drugs (DMARDs) are a group of medicines that are used to ease the symptom av rheumatoid arthritis (RA) and reduce the damaging effect.
Patient information leaflet
Asbestrelaterade sjukdomar
People exposed to asbestos can develop diseases in later life. These most commonly affect the lungs but can also affect the lining of the tummy (abdomen). Some conditions - for example, mesothelioma or lung cancer - are more serious than others. This leaflet gives a brief overview of the diseases that are related to having an exposure to asbestos.
Patient information leaflet
Buerger's sjukdom
Buerger's disease causes inflammation of blood vessels in the legs and arms, particularly in the hands and feet. It leads to narrowing and blockage of the blood vessels so that blood flow to the hands and feet is reduced. This causes pain ... What is Buerger's disease. Buerger's sjukdom is a condition that causes inflammation of the small- and.
Patient information leaflet
Sköldkörtelögonsjukdom
Thyroid eye disease causes the muscles and soft tissues within the eye socket to swell. This is most often due to an autoimmune disease. Autoimmune thyroid disease Thyroid eye disease is an autoimmune disease, most often occurring in association with an overactive thyroid gland (hyperthyroidism). The immune system normally makes small proteins.
Vidare läsning och referenser
- Autoimmune Addison disease; MedlinePlus, National Library of Medicine.
- Gombos Z, Hermann R, Kiviniemi M, Nejentsev S, Reimand K, Fadeyev V, Peterson P, Uibo R, Ilonen J. Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. Eur J Endocrinol. 2007 Dec;157(6):757-61. doi: 10.1530/EJE-07-0290.
- Husebye E, Lovas K. Pathogenesis of primary adrenal insufficiency. Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):147-57. doi: 10.1016/j.beem.2008.09.004.
- Mitchell AL, Pearce SH. Autoimmune Addison disease: pathophysiology and genetic complexity. Nat Rev Endocrinol. 2012 Jan 31;8(5):306-16. doi: 10.1038/nrendo.2011.245.
- Napier C, Pearce SH. Autoimmune Addison's disease. Presse Med. 2012 Dec;41(12 P 2):e626-35. doi: 10.1016/j.lpm.2012.09.010. Epub 2012 Nov 21.
- Rottembourg D, Deal C, Lambert M, Mallone R, Carel JC, Lacroix A, Caillat-Zucman S, le Deist F. 21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease. J Autoimmun. 2010 Dec;35(4):309-15. doi: 10.1016/j.jaut.2010.07.001. Epub 2010 Aug 3.
- Skinningsrud B, Lie BA, Lavant E, Carlson JA, Erlich H, Akselsen HE, Gervin K, Wolff AB, Erichsen MM, Lovas K, Husebye ES, Undlien DE. Multiple loci in the HLA complex are associated with Addison's disease. J Clin Endocrinol Metab. 2011 Oct;96(10):E1703-8. doi: 10.1210/jc.2011-0645. Epub 2011 Aug 3.
- Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu SR, Gottlieb PA, Freed BM, Noble J, Erlich HA, Rewers MJ, Eisenbarth GS. DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab. 1999 Jan;84(1):328-35. doi: 10.1210/jcem.84.1.5414.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
17 Mar 2026 | Senaste versionen
1 Jun 2014 | Ursprungligen publicerad
Delta i konversationen
Dela dina tankar eller erfarenheter med andra i vår patientgemenskaper.
Fråga, dela, anslut.
Bläddra i diskussioner, ställ frågor och dela erfarenheter inom hundratals hälsorelaterade ämnen.
Anmäl dig till Patientens nyhetsbrev
Din veckovisa dos av tydliga, pålitliga hälsoråd - skrivna för att hjälpa dig känna dig informerad, självsäker och i kontroll.
Genom att prenumerera accepterar du våra Sekretesspolicy. Du kan avsluta prenumerationen när som helst. Vi säljer aldrig dina uppgifter.