Nagelpsoriasis

What is nail psoriasis?

Psoriatic nail disease is a type of psoriasis. It is not caused by infection and you cannot pass it on to anyone else.

Psoriasis is a common skin condition that usually causes patches (plaques) of red, scaly skin but sometimes affects the nails and cuticles. There is also a form of arthritis that is linked to psoriasis, called psoriatic arthritis. Psoriatic nail disease is particularly common if you have psoriatic arthritis. You can read more about these conditions in the separate leaflets called Psoriasis och Psoriatic Arthritis.

Nail psoriasis is caused by the same processes as psoriasis elsewhere. Skin cells grow abnormally rapidly, causing a layer of immature, poorly-functioning skin cells to emerge on the outermost layer of the skin. The immune system is involved in this process, as it seems to attack healthy skin cells by mistake, and trigger skin cells to divide and grow too quickly.

The symptoms and signs of nail psoriasis depend on which part of the nail is affected by psoriasis. For example:

• If the nail matrix - the part which produces new nails - is affected, small areas of abnormal cells develop in patches on the nail. As the nail grows, those patches deepen and cause pitting of the nail plate (the hard part of the nail).

• If an area of psoriasis grows in the nail bed (the area beneath the nail plate), it can push the nail plate up, detaching the nail plate from the nail bed (onycholysis).

Psoriatic nail

© Seenms, CC BY-SA 3.0, via Wikimedia Commons

Nail psoriasis can affect fingernails and toenails. There are different types of nail changes that can occur. Signs of nail psoriasis include:

Pitting of the nails

Small pits appear on the surface of the nail. There may be one pit or many pits on the surface of a single nail.

Onycholysis

The nail separates from the skin underneath the nail. At first this looks like a white or yellow patch at the tip of the nail. This patch gradually gets bigger and reaches the base of the nail. The gap between the nail and the skin underneath the nail can become infected and change colour.

Subungual hyperkeratosis

A chalk-like material builds up under the nail. The nail becomes raised and often tender.
Oil drop or salmon patch - a see-through yellow-red patch appears in the nail bed that looks like there is a drop of oil under the nail.

Colour

The colour of the nail may change, such as turning to yellow-brown.

Infektioner of the nail can occur at the same time as psoriatic nail disease and can sometimes look like nail psoriasis. Fungal nail infections also cause thickening of the nails. It is important to get the correct treatment as some treatments for fungal nail diseases (eg, terbinafin) can aggravate nail psoriasis.

Onycholysis is the loosening or separation of the nail from the skin underneath it. Treatment depends on the cause. Apart from nail psoriasis it has many other causes - for example:

• Trauma to the nail bed - for example, by repeated tapping of the fingernails on a keyboard or by pressure from shoes in long-distance runners and walkers.

• Allergy to nail glue (acrylate).

• Infections, such as fungal infections, bacterial infections, or the cold sore virus (herpes simplex).

• Many medicines - for example, some forms of chemotherapy for cancer, and tetracycline and fluoroquinolone antibiotics.

• Other diseases, such as diabetes or thyroid disease.

In most of these situations the onycholysis is not permanent and the nail will grow out normally once the cause has been removed or treated.

About 1 in 50 people have psoriasis at some time in their lives. It can first develop at any age but it most often starts between the ages of 15 and 30 years. Nail changes occur in about half of all people with psoriasis, so about 1 in a 100 people get nail psoriasis.

About 4 in every 5 people with psoriatic arthritis have psoriatic nail disease. See the separate leaflet called Psoriatic Arthritis for more details.

Only a few people have psoriatic nail disease without having psoriasis affecting either their skin or their joints.

The diagnosis of psoriatic nail disease is usually made by the appearance of the affected nails. Sometimes scrapings from under the nail, and nail clippings, are sent to the laboratory to be tested for fungal infection of the nail, which can sometimes look like psoriatic nail disease.

Occasionally, a sample of nail (a biopsy) is needed to confirm the diagnosis.

• Keep your fingernails and toenails as short as possible - long or loose nails are more likely to catch and can cause more damage to the skin underneath the nail.

• Keep your nails dry.

• Protect your nails and wear gloves when doing any manual work.

• Avoid a manicure of the base of the nail. This may cause an infection.

• Avoid false nails as they may damage the cuticle and make it difficult to apply treatments to the nail.

• Nail varnish can be used to cover up pitting. Nail varnish remover containing acetone should not be used, as it can cause damage to the nail.

• If you have painful toenail psoriasis then you should see a person who is qualified to diagnose and treat foot disorders (a podiatrist).

Mild nail disease which isn't causing discomfort does not need any treatment. If the nail disease is severe and causing problems then your doctor may refer you to see a skin specialist for advice and treatment. Unfortunately treatment of psoriatic nail disease is difficult and not always successful.

Treatments for nail psoriasis include:

• Treatments applied to the nail, which include steroids, salicylic acid, calcipotriol or tazarotene. Local treatments applied to the nail are often not very effective in treating nail psoriasis but are worth trying. If the nail is lifting off (onycholysis) then strong steroid scalp application can be trickled under the nail.

• Antifungal treatment - this may be required for fungal nail infection if this is also present.

• A steroid injected into the nail - this may be effective for some types of nail psoriasis but it is painful.

• Light therapy (phototherapy) - psoralen plus ultraviolet light A (PUVA) treatment is effective for some types of nail psoriasis but not for pitting of the nail.

• Removing an affected nail - this can be done by applying a special type of ointment and then covering the nail for seven days. Otherwise the nail can be surgically removed using local anaesthetic.

Patience is important. Once the nail has formed, nothing can be done to change it other than trimming it. The treatments are all aimed at treating the nail bed and the skin around the edge of the nail. Nails grow extremely slowly and it may take as long as a year for a damaged fingernail to grow out completely, or even two years for a damaged big toenail.

If nail psoriasis is severe and not helped by the treatments listed above then a powerful medicine which can suppress inflammation is sometimes used. For example, methotrexate, ciclosporin, acitretin, infliximab, etanercept, efalizumab, ustekinumab or adalimumab. There is some risk of serious side-effects with these medicines, so they are only used on the advice of a specialist and usually when there is psoriasis also affecting the skin.

Nail psoriasis can be difficult to treat and there is no cure. It doesn't usually grow out without treatment, so can continue to cause problems. The appearance of the affected nails can also sometimes cause distress.

The treatment of severe psoriatic nail disease is now improving with modern medicines.

Psoriatic nail disease can also be mild, not needing any treatment, and able to be hidden with nail varnish.