chloride voltage-gated channel 2
Senast uppdaterad 18 aug 2020
Uppfyller patientens redaktionella riktlinjer
- Ladda nerLadda ner
- Dela
- Language
- Diskussion
- Ljudversion
- Lägg till i föredragna källor på Google
Den CLCN2 gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some chloride channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
Normal function
Den CLCN2 gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some chloride channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
Den CLCN2 gene provides instructions for making a chloride channel called ClC-2. These channels are embedded within the outer membrane of most cells, and they transport chloride ions in and out of cells. The channel's function is thought to be particularly important in nerve cells (neurons) in the brain. The ClC-2 channel regulates the size (volume) of neurons by playing a role in the intake and release of water as well as maintaining a normal balance of ions in cells.
Conditions referring to this gene or chromosome
Other names
chloride channel 2
chloride channel, voltage-sensitive 2
CIC-2
clC-2
CLC2
ECA2
ECA3
EGI11
EGI3
EGMA
EJM6
EJM8
LKPAT
Related patient information and medicines
Patient information leaflet
Cystisk fibros
Cystic fibrosis is an inherited disease which mainly affects the lungs and pancreas but can involve other organs. Symptoms usually begin in early childhood and include persistent cough, wheeze, repeated chest infections, difficulty digesting food and general ill health. Treatments include antibiotics, physiotherapy, medicines for thinning mucus,.
Patient information leaflet
Njurcancer
This is sometimes called renal adenocarcinoma or renal cell carcinoma or hypernephroma. Renal cell cancer This type of cancer develops from a cell in a kidney tubule, which becomes cancerous (malignant). The cancer grows and forms into a tumour within the kidney. As the tumour grows: The affected kidney tends to become larger. In time the tumour.
Patient information leaflet
Brännskador och skållningar
Burns caused b... For electrical burns - disconnect the victim from the source of electricity before attempting first aid. If you cannot switch off the electricity: If the person has been injured by a low-voltage source (220-240 volts, domestic electricity supply) then remove the person from the electrical source, using a non-conductive material.
Patient information leaflet
Svettiga fötter
It may lead to smelly feet, and nobody likes stinky feet. This leaflet explains why feet sweat (which is normal) and how to stop your feet from being sweaty or smelly. Why do feet sweat. Sweating is normal. It has three main functions: Heat regulation - sweating cools the body by wetting the surface of the skin. Excretion - another way for the.
Patient information leaflet
Akut bihåleinflammation
Chronic sinusitis This means that an episode of sinusitis becomes persistent and lasts longer than 12 weeks. Chronic sinusitis is common affecting 1 in 10 adults in the UK. See the separate leaflet called Chronic sinusitis for more details. The rest of this leaflet is about acute sinusitis. Acute sinusitis symptoms Common symptoms of sinusitis.
Patient information leaflet
Näspolyper
Side-effects of topical steroid medications These include nasal irritation, sore throat and nosebleeds. About 1 in 10 people using these medications will experience one of these symptoms. Some people are sensitive to a preservative called benzalkonium chloride, found in all all nasal steroid treatments (drops and sprays), except for Flixonase.
Vidare läsning och referenser
- chloride voltage-gated channel 2; MedlinePlus, National Library of Medicine.
- Gaitan-Penas H, Apaja PM, Arnedo T, Castellanos A, Elorza-Vidal X, Soto D, Gasull X, Lukacs GL, Estevez R. Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking. J Physiol. 2017 Nov 15;595(22):6993-7008. doi: 10.1113/JP275087. Epub 2017 Oct 9.
- Stolting G, Fischer M, Fahlke C. CLC channel function and dysfunction in health and disease. Front Physiol. 2014 Oct 7;5:378. doi: 10.3389/fphys.2014.00378. eCollection 2014.
- Wang H, Xu M, Kong Q, Sun P, Yan F, Tian W, Wang X. Research and progress on ClC‑2 (Review). Mol Med Rep. 2017 Jul;16(1):11-22. doi: 10.3892/mmr.2017.6600. Epub 2017 May 18.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
18 aug 2020 | Senaste versionen
1 Dec 2017 | Ursprungligen publicerad
Delta i konversationen
Dela dina tankar eller erfarenheter med andra i vår patientgemenskaper.
Fråga, dela, anslut.
Bläddra i diskussioner, ställ frågor och dela erfarenheter inom hundratals hälsorelaterade ämnen.
Anmäl dig till Patientens nyhetsbrev
Din veckovisa dos av tydliga, pålitliga hälsoråd - skrivna för att hjälpa dig känna dig informerad, självsäker och i kontroll.
Genom att prenumerera accepterar du våra Sekretesspolicy. Du kan avsluta prenumerationen när som helst. Vi säljer aldrig dina uppgifter.