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The MEN1 gene provides instructions for making a protein called menin. This protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing (proliferating) too fast or in an uncontrolled way. Menin is present in the nucleus of many different types of cells and is likely involved in several important cell functions. It may play a role in copying and repairing DNA and in regulating the controlled self-destruction of cells (apoptosis).
Normal function
The MEN1 gene provides instructions for making a protein called menin. This protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing (proliferating) too fast or in an uncontrolled way. Menin is present in the nucleus of many different types of cells and is likely involved in several important cell functions. It may play a role in copying and repairing DNA and in regulating the controlled self-destruction of cells (apoptosis).
Menin interacts with many other proteins, including several transcription factors. Transcription factors bind to specific areas of DNA and help turn particular genes on or off. Some of these genes likely play a role in cell proliferation.
Conditions referring to this gene or chromosome
Other names
MEAI
MEN1_HUMAN
menin
Related patient information and medicines
Patient information leaflet
Förmaksflimmer och förebyggande av stroke
The medicines used to prevent a atrial fibrillation-related stroke are called anticoagulants. These help to stop blood clots forming in your blood vessels. Everyone with a score of 2 or more should be treated with anticoagulation. Men with a risk of 1 may be offered anticoagulation. Women with a risk of 1 (in other words, where female sex is their.
Patient information leaflet
Resa till avlägsna platser
Self-treatment is a last resort as it is very difficult for anyone to make treatment decisions about themselves. Reference book Pocket First Aid and Wilderness Medicine: Drs Jim Duff and Peter Gormly (2010). This is an excellent handbook covering what to do as a layperson in most medical situations you might encounter. Equipment Thermom....
Patient information leaflet
Meningokockinfektion
Neisseria meningitidis , also known as meningococcus, is a germ (bacterium). Infection with meningococcus is uncommon but is very serious and can be life-threatening. Meningococcal infection is one of the most common causes of bacterial meningitis. If you suspect meningitis or sepsis -get medical help immediately by calling for an emergency.
Patient information leaflet
Pneumokockvaccination
Pneumokocker can cause diseases such as pneumonia, meningitis and blood infections. The first is usually given at the same time as the second dose of the 6-in-1 DTaP/IPV(polio)/Hib/HepB injection - this stands for 'diphtheria, tetanus, pertussis (whooping cough)/polio/Haemophilus inf... The second dose, at about one year, is usually given at the.
Patient information leaflet
5:2 diet
The 5:2 diet is a calorie-restricted diet that involves eating 'normally' for five days out of seven and then 'fasting' on the other two days out of seven. The 500 or 600 calories can be eaten throughout the day as snacks, or as one or two meals. It is recommended that good foods to eat on a 'fasting' day are foods high in protein and fibre which.
Patient information leaflet
Skoluteslutning vid infektioner
This leaflet provides brief information about common childhood infections and whether or not children should go to school, nursery or other childcare. Doctors are often asked about incubation times for the common childhood infections, so that they can advise whether the child should go to school, nursery or other childcare. Risk of serious.
Vidare läsning och referenser
- menin 1; MedlinePlus, National Library of Medicine.
- Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ. Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res. 2005 Jun;37(6):369-74. doi: 10.1055/s-2005-870139.
- Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Molecular pathology of the MEN1 gene. Ann N Y Acad Sci. 2004 Apr;1014:189-98. doi: 10.1196/annals.1294.020.
- Cetani F, Pardi E, Aretini P, Saponaro F, Borsari S, Mazoni L, Apicella M, Civita P, La Ferla M, Caligo MA, Lessi F, Mazzanti CM, Torregossa L, Oppo A, Marcocci C. Whole exome sequencing in familial isolated primary hyperparathyroidism. J Endocrinol Invest. 2020 Feb;43(2):231-245. doi: 10.1007/s40618-019-01107-5. Epub 2019 Sep 5.
- Davenport C, Agha A. The role of menin in parathyroid tumorigenesis. Adv Exp Med Biol. 2009;668:79-86. doi: 10.1007/978-1-4419-1664-8_8.
- Hannan FM, Nesbit MA, Christie PT, Fratter C, Dudley NE, Sadler GP, Thakker RV. Familial isolated primary hyperparathyroidism caused by mutations of the MEN1 gene. Nat Clin Pract Endocrinol Metab. 2008 Jan;4(1):53-8. doi: 10.1038/ncpendmet0718.
- La P, Desmond A, Hou Z, Silva AC, Schnepp RW, Hua X. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene. 2006 Jun 15;25(25):3537-46. doi: 10.1038/sj.onc.1209400. Epub 2006 Jan 30.
- Lemos MC, Thakker RV. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat. 2008 Jan;29(1):22-32. doi: 10.1002/humu.20605.
- Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer. 2005 May;5(5):367-75. doi: 10.1038/nrc1610.
- Matkar S, Thiel A, Hua X. Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci. 2013 Aug;38(8):394-402. doi: 10.1016/j.tibs.2013.05.005. Epub 2013 Jul 10.
- Pannett AA, Kennedy AM, Turner JJ, Forbes SA, Cavaco BM, Bassett JH, Cianferotti L, Harding B, Shine B, Flinter F, Maidment CG, Trembath R, Thakker RV. Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism. Clin Endocrinol (Oxf). 2003 May;58(5):639-46. doi: 10.1046/j.1365-2265.2003.01765.x.
- Tsukada T, Nagamura Y, Ohkura N. MEN1 gene and its mutations: basic and clinical implications. Cancer Sci. 2009 Feb;100(2):209-15. doi: 10.1111/j.1349-7006.2008.01034.x.
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23 Jan 2026 | Senaste versionen
1 Jan 2026 | Ursprungligen publicerad
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