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Can I take Devil's claw and Evening primrose oil together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelines

Taking devil's claw and evening primrose oil together may increase your risk of bruising or bleeding. This is because both supplements can thin the blood or slow down the clotting process. While the risk is generally low for healthy individuals, it is more significant if you are already taking blood-thinning medications or have an upcoming surgery.

Why this happens

Both supplements have 'antiplatelet' effects. This means they make the tiny cells in your blood (platelets) less 'sticky', which makes it harder for your blood to form clots. When used together, this effect is added together (an additive effect).

What you should do

You should use this combination with caution. Watch for signs of unusual bleeding, such as bleeding gums, nosebleeds, or easy bruising. If you are scheduled for any surgery or dental work, stop taking both supplements at least two weeks before the procedure. Consult your doctor before combining these if you take blood-thinning medicines like warfarin, aspirin, or clopidogrel.

Important precautions

Stomach ulcers or gallstones

Devil's claw can increase stomach acid and stimulate bile production, which may worsen stomach ulcers, duodenal ulcers, or gallstones.

Diabetes

Devil's claw may lower blood sugar levels; you must monitor your blood glucose closely as your diabetes medication dosage may need adjustment.

Heart rhythm disorders (arrhythmias)

Devil's claw can affect heart rate and blood pressure; use with caution if you have a heart condition or take blood pressure medication.

Epilepsy or Schizophrenia

Evening primrose oil may increase the risk of seizures (fits), particularly in people with a history of epilepsy or those taking phenothiazine medications for schizophrenia.

Bleeding disorders or surgery

These supplements can increase the risk of bruising and bleeding. You must stop taking them at least two weeks before any scheduled surgery.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking Devil's Claw. Devil's Claw can increase the production of stomach acid, and alcohol is a known stomach irritant. Combining them may increase the risk of stomach upset, irritation, or gastric ulcers. Additionally, both substances are processed by the liver; combining them may increase the strain on liver function.

It is best to avoid or strictly limit alcohol when taking evening primrose oil. While there is no direct chemical interaction, both substances can lower the seizure threshold in susceptible individuals, and alcohol may worsen the side effects of the supplement, such as nausea or indigestion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.

  • 25 Jan 2026 | Originally published
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